Selective Participation of Single Cortical Neurons in Neuronal Avalanches

doi:10.3389/fncir.2020.620052

	Selective Participation of Single Cortical Neurons in Neuronal Avalanches
	Bellay, Timothy 1,5; Shew, Woodrow L.4,5; Yu, Shan 3,5; Falco-Walter, Jessica J.2,5; Plenz, Dietmar 5
刊名	FRONTIERS IN NEURAL CIRCUITS
	2021-01-22
卷号	14 页码:18
关键词	nonhuman primate rat prefrontal cortex primary motor cortex high-density microelectrode array local field potential whole-cell patch recording cell assemblies
DOI	10.3389/fncir.2020.620052
通讯作者	Plenz, Dietmar(plenzd@mail.nih.gov)
英文摘要	Neuronal avalanches are scale-invariant neuronal population activity patterns in the cortex that emerge in vivo in the awake state and in vitro during balanced excitation and inhibition. Theory and experiments suggest that avalanches indicate a state of cortex that improves numerous aspects of information processing by allowing for the transient and selective formation of local as well as system-wide spanning neuronal groups. If avalanches are indeed involved with information processing, one might expect that single neurons would participate in avalanche patterns selectively. Alternatively, all neurons could participate proportionally to their own activity in each avalanche as would be expected for a population rate code. Distinguishing these hypotheses, however, has been difficult as robust avalanche analysis requires technically challenging measures of their intricate organization in space and time at the population level, while also recording sub- or suprathreshold activity from individual neurons with high temporal resolution. Here, we identify repeated avalanches in the ongoing local field potential (LFP) measured with high-density microelectrode arrays in the cortex of awake nonhuman primates and in acute cortex slices from young and adult rats. We studied extracellular unit firing in vivo and intracellular responses of pyramidal neurons in vitro. We found that single neurons participate selectively in specific LFP-based avalanche patterns. Furthermore, we show in vitro that manipulating the balance of excitation and inhibition abolishes this selectivity. Our results support the view that avalanches represent the selective, scale-invariant formation of neuronal groups in line with the idea of Hebbian cell assemblies underlying cortical information processing.
资助项目	Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH)[ZIAMH002797]
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000614749200001
资助机构	Division of the Intramural Research Program (DIRP) of the National Institute of Mental Health (NIMH)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/42858]
专题	自动化研究所_脑网络组研究中心
通讯作者	Plenz, Dietmar
作者单位	1.Brown Univ, Dept Neurosci, Providence, RI 02912 USA 2.Stanford Univ, Dept Neurol, Palo Alto, CA 94304 USA 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 4.Univ Arkansas, Dept Phys, Fayetteville, AR 72701 USA 5.NIMH, Sect Crit Brain Dynam, NIH, Bethesda, MD 20892 USA
推荐引用方式 GB/T 7714	Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,et al. Selective Participation of Single Cortical Neurons in Neuronal Avalanches[J]. FRONTIERS IN NEURAL CIRCUITS,2021,14:18.
APA	Bellay, Timothy,Shew, Woodrow L.,Yu, Shan,Falco-Walter, Jessica J.,&Plenz, Dietmar.(2021).Selective Participation of Single Cortical Neurons in Neuronal Avalanches.FRONTIERS IN NEURAL CIRCUITS,14,18.
MLA	Bellay, Timothy,et al."Selective Participation of Single Cortical Neurons in Neuronal Avalanches".FRONTIERS IN NEURAL CIRCUITS 14(2021):18.