Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia

doi:10.1016/j.neuroscience.2020.08.021

	Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia
	He, Yuwen 5,6; Wu, Shihao 4; Chen, Cheng 4; Fan, Lingzhong 3; Li, Kaixin 1; Wang, Gaohua 4; Wang, Huiling 4; Zhou, Yuan 2,5,6
刊名	NEUROSCIENCE
	2020-10-15
卷号	446 页码:14-27
关键词	prefrontal cortex schizophrenia Brief Assessment of Cognition in Schizophrenia dysconnectivity hypothesis resting-state functional connectivity
ISSN号	0306-4522
DOI	10.1016/j.neuroscience.2020.08.021
通讯作者	Zhou, Yuan(zhouyuan@psych.ac.cn)
英文摘要	Schizophrenia has prominent functional dysconnectivity, especially in the prefrontal cortex (PFC). However, it is unclear whether in the same group of patients with schizophrenia, PFC functional dysconnectivity appears in an organized manner or is stochastically located in different subregions. By investigating the restingstate functional connectivity (rsFC) of each PFC subregion from the Brainnetome atlas in 40 schizophrenia patients and 40 healthy subjects, we found 24 altered connections in schizophrenia, and the connections were divided into four categories by a clustering analysis: increased connections within the PFC, increased connections between the inferior PFC and the thalamus/striatum, reduced connections between the PFC and the motor control areas, and reduced connections between the orbital PFC and the emotional perception regions. In addition, the four categories of rsFC showed distinct cognitive engagement patterns. Our findings suggest that PFC subregions have specific functional dysconnectivity patterns in schizophrenia and may reflect heterogeneous symptoms and cognitive deficits in schizophrenia. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[81771473] ; National Natural Science Foundation of China[81371476] ; National Natural Science Foundation of China[91432302]
WOS关键词	NEUROLOGICAL SOFT SIGNS ; BRAIN NETWORKS ; PARANOID SCHIZOPHRENIA ; WORKING-MEMORY ; HEAD MOTION ; CONNECTIVITY ; FMRI ; DYSFUNCTION ; ASSOCIATION ; COGNITION
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000577243000002
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/42107]
专题	自动化研究所_脑网络组研究中心
通讯作者	Zhou, Yuan
作者单位	1.Harbin Univ Sci & Technol, Harbin 150080, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 4.Wuhan Univ, Renmin Hosp, Dept Psychiat, Wuhan, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Magnet Resonance Imaging Res Ctr, 16 Lincui Rd, Beijing 100101, Peoples R China 6.Chinese Acad Sci, Inst Psychol, CAS Key Lab Behav Sci, 16 Lincui Rd, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	He, Yuwen,Wu, Shihao,Chen, Cheng,et al. Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia[J]. NEUROSCIENCE,2020,446:14-27.
APA	He, Yuwen.,Wu, Shihao.,Chen, Cheng.,Fan, Lingzhong.,Li, Kaixin.,...&Zhou, Yuan.(2020).Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia.NEUROSCIENCE,446,14-27.
MLA	He, Yuwen,et al."Organized Resting-state Functional Dysconnectivity of the Prefrontal Cortex in Patients with Schizophrenia".NEUROSCIENCE 446(2020):14-27.