Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles

doi:10.1007/s12264-020-00589-1

	Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles
	He, Bin 1,2,10; Cao, Long 8,10; Xia, Xiaoluan 5,10; Zhang, Baogui 2,10; Zhang, Dan 3; You, Bo 1; Fan, Lingzhong 2,6,9,10; Jiang, Tianzi 2,4,6,7,8,9,10
刊名	NEUROSCIENCE BULLETIN
	2020-10-27
页码	20
关键词	Macaque Frontal pole cortex Anatomical connectivity profile Parcellation Neuroimaging Principal component analysis
ISSN号	1673-7067
DOI	10.1007/s12264-020-00589-1
通讯作者	You, Bo(youbo@hrbust.edu.cn) ; Fan, Lingzhong(lingzhong.fan@ia.ac.cn) ; Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn)
英文摘要	The frontal pole cortex (FPC) plays key roles in various higher-order functions and is highly developed in non-human primates. An essential missing piece of information is the detailed anatomical connections for finer parcellation of the macaque FPC than provided by the previous tracer results. This is important for understanding the functional architecture of the cerebral cortex. Here, combining cross-validation and principal component analysis, we formed a tractography-based parcellation scheme that applied a machine learning algorithm to divide the macaque FPC (2 males and 6 females) into eight subareas using high-resolution diffusion magnetic resonance imaging with the 9.4T Bruker system, and then revealed their subregional connections. Furthermore, we applied improved hierarchical clustering to the obtained parcels to probe the modular structure of the subregions, and found that the dorsolateral FPC, which contains an extension to the medial FPC, was mainly connected to regions of the default-mode network. The ventral FPC was mainly involved in the social-interaction network and the dorsal FPC in the metacognitive network. These results enhance our understanding of the anatomy and circuitry of the macaque brain, and contribute to FPC-related clinical research.
资助项目	National Natural Science Foundation of China[91432302] ; National Natural Science Foundation of China[31620103905] ; Science Frontier Program of the Chinese Academy of Sciences[QYZDJ-SSW-SMC019] ; National Key R&D Program of China[2017YFA0105203] ; Beijing Municipal Science and Technology Commission[Z161100000216152] ; Beijing Municipal Science and Technology Commission[Z161100000216139] ; Beijing Municipal Science and Technology Commission[Z181100001518004] ; Beijing Municipal Science and Technology Commission[Z171100000117002] ; Beijing Brain Initiative of Beijing Municipal Science and Technology Commission[Z181100001518004] ; Guangdong Pearl River Talents Plan[2016ZT06S220]
WOS关键词	PREFRONTAL CORTICAL PROJECTIONS ; DIFFUSION TRACTOGRAPHY ; ARCHITECTONIC SUBDIVISION ; FRONTOPOLAR CORTEX ; BRAIN ; PARCELLATION ; NETWORKS ; ORGANIZATION ; AREAS ; PATHWAYS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000584623300002
资助机构	National Natural Science Foundation of China ; Science Frontier Program of the Chinese Academy of Sciences ; National Key R&D Program of China ; Beijing Municipal Science and Technology Commission ; Beijing Brain Initiative of Beijing Municipal Science and Technology Commission ; Guangdong Pearl River Talents Plan
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/41762]
专题	自动化研究所_脑网络组研究中心
通讯作者	You, Bo; Fan, Lingzhong; Jiang, Tianzi
作者单位	1.Harbin Univ Sci & Technol, Sch Mech & Power Engn, Harbin 150080, Peoples R China 2.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 3.Tsinghua Univ, Ctr Biomed Anal, Core Facil, Beijing 100084, Peoples R China 4.Chinese Inst Brain Res, Beijing 102206, Peoples R China 5.Taiyuan Univ Technol, Coll Informat & Comp, Taiyuan 030600, Peoples R China 6.Univ CAS, Beijing 100049, Peoples R China 7.Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia 8.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu 610054, Peoples R China 9.Chinese Acad Sci, Inst Automat, Ctr Excellence Brain Sci & Intelligence Technol, Beijing 100190, Peoples R China 10.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	He, Bin,Cao, Long,Xia, Xiaoluan,et al. Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles[J]. NEUROSCIENCE BULLETIN,2020:20.
APA	He, Bin.,Cao, Long.,Xia, Xiaoluan.,Zhang, Baogui.,Zhang, Dan.,...&Jiang, Tianzi.(2020).Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles.NEUROSCIENCE BULLETIN,20.
MLA	He, Bin,et al."Fine-Grained Topography and Modularity of the Macaque Frontal Pole Cortex Revealed by Anatomical Connectivity Profiles".NEUROSCIENCE BULLETIN (2020):20.