Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics

doi:10.1021/acs.bioconjchem.0c00594

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics
	Jin, Yushen 3,4; Tang, Chu 2; Tian, Jie 1; Shao, Bing 3,4
刊名	BIOCONJUGATE CHEMISTRY
	2021-01-20
卷号	32 期号:1 页码:161-171
ISSN号	1043-1802
DOI	10.1021/acs.bioconjchem.0c00594
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Shao, Bing(shaobingch@sina.com)
英文摘要	Early identification and treatment of breast cancer is very important for breast conserving therapy and to improve the prognosis and survival rates of patients. Multifunctional nanotheranostic agents are of particular importance in the field of precise nanomedicine, since they can augment the visualization and treatment of cancer. We developed a novel Bi2S3 nanoparticle coated with a hyaluronic acid (HA)-modified tantalum oxide (TaOx) nanoshell (Bi2S3@TaOx-HA). The as-prepared core/shell nanoparticles exhibited a high BO, nanoparticle loading efficiency of (67 wt %). The TaOx nanoshell exhibited excellent biocompatibility and computed tomography imaging capacity, and the Bi2S3 nanoparticles exhibited an excellent photothermal transducing performance and computed tomography (CT) and photoacoustic imaging capacity. As a result of these merits, the Bi2S3@TaOx core-shell nanoparticles can act as a theranostic agent for CT/photoacoustically monitored enhanced photothermal therapy. These findings will evoke new interest in future cancer therapeutic strategies based on biocompatible functional nanomaterials.
资助项目	National Key Research and Development Program of China[2019YFC1604600] ; National Natural Science Foundation of China[82072098] ; National Natural Science Foundation of China[81701771]
WOS关键词	PHOTOTHERMAL THERAPY ; DRUG-RELEASE ; NANOPARTICLES ; OXIDE ; CHEMOTHERAPY ; AGENTS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000612551500017
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/43243]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Shao, Bing
作者单位	1.Chinese Acad Sci, Inst Automat, Beijing 100190, Peoples R China 2.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Sch Life Sci & Technol, Minist Educ, Xian 710126, Shaanxi, Peoples R China 3.Beijing Ctr Dis Prevent & Control, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China 4.Beijing Ctr Dis Prevent Med Res, Cent Res Lab, Beijing 100013, Peoples R China
推荐引用方式 GB/T 7714	Jin, Yushen,Tang, Chu,Tian, Jie,et al. Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics[J]. BIOCONJUGATE CHEMISTRY,2021,32(1):161-171.
APA	Jin, Yushen,Tang, Chu,Tian, Jie,&Shao, Bing.(2021).Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics.BIOCONJUGATE CHEMISTRY,32(1),161-171.
MLA	Jin, Yushen,et al."Integration of TaOx with Bi2S3 for Targeted Multimodality Breast Cancer Theranostics".BIOCONJUGATE CHEMISTRY 32.1(2021):161-171.