Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer

doi:10.1021/acsami.0c15176

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer
	Guo, Pengyu 1,3,4; Wang, Lu 3,4; Shang, Wenting 1; Chen, Jiuwei 3,4; Chen, Ziyin 3,4; Xiong, Feng 3,4; Wang, Ziqi 3,4; Tong, Zhichao 3,4; Wang, Keliang 3,4; Yang, Liming 2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-12-09
卷号	12 期号:49 页码:54367-54377
关键词	bladder cancer ferroptosis macrophage intravesical therapy PTT
ISSN号	1944-8244
DOI	10.1021/acsami.0c15176
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Xu, Wanhai(xuwanhai@163.com)
英文摘要	Bladder cancer displays multiple biological features aided in drug resistance; therefore, single therapy fails to induce complete tumor regression. To address this issue, various kinds of cell death of cancer cells as well as restoring tumor immune microenvironment need to be taken into consideration. Here, we introduce a gel system termed AuNRs&IONs@Gel, which target-delivers a combination of photothermal, ferroptotic, and immune therapy through intravesical instillation. AuNRs&IONs@Gel consists of a gel delivery platform, embedded gold nanorods (AuNRs), and iron oxide nanoparticles (IONs). The targeted delivery gel platform provides dextran aldehyde-selective adhesion with cancer collagen. In this condition, photothermal therapy can be performed by gold nanorods (AuNRs) under imaging-guided near-infrared radiation. Local high concentrations of IONs can be absorbed by cancer cell to induce ferroptosis. Moreover, tumor-associated macrophages which often display an immune-suppressive M2-like phenotype will be repolarized by IONs into the antitumor M1-like phenotype, exerting a direct antitumor effect and professional antigen presentation of dead cancer cells. This process triggers a potent immune response of innate and adapt immunities to protect tumor rechallenge in long terms. Our triple therapy strategy employs FDA-approved nanoparticles to inhibit bladder cancer which may possess great potential for clinical translation.
资助项目	National Natural Science Foundation of China[81771898] ; National Natural Science Foundation of China[51903069] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202001] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HY-DSYYXQN202003] ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University[HYDSYYXQN202004] ; Fundamental Research Funds for the Provincial Universities[2019-KYYWF-0372] ; China Postdoctoral Science Foundation[2020M680047] ; Special project of Heilongjiang Postdoctoral Fund[LBH-TZ1017] ; Applied Technology Research and Development Project of Heilongjiang Province[GY2019YF0086]
WOS关键词	NANOMEDICINE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000599505200009
资助机构	National Natural Science Foundation of China ; Excellent Youth Project of the Fourth Affiliated Hospital of Harbin Medical University ; Fundamental Research Funds for the Provincial Universities ; China Postdoctoral Science Foundation ; Special project of Heilongjiang Postdoctoral Fund ; Applied Technology Research and Development Project of Heilongjiang Province
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/42734]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Xu, Wanhai
作者单位	1.Chinese Acad Sci, CAS Key Lab Mol Imaging, State Key Lab Management & Control Complex Syst, Inst Automat, Beijing 100190, Peoples R China 2.Harbin Med Univ, Dept Pathophysiol, Key Lab Cardiovasc Pathophysiol, Harbin 150081, Peoples R China 3.Harbin Med Univ, Hosp 4, Urol Surg Dept, Heilongjiang Key Lab Sci Res Urol, Harbin 150081, Peoples R China 4.Harbin Med Univ, Hosp 4, NHC Key Lab Mol Probes & Targeted Diag & Therapy, Harbin 150081, Peoples R China
推荐引用方式 GB/T 7714	Guo, Pengyu,Wang, Lu,Shang, Wenting,et al. Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(49):54367-54377.
APA	Guo, Pengyu.,Wang, Lu.,Shang, Wenting.,Chen, Jiuwei.,Chen, Ziyin.,...&Xu, Wanhai.(2020).Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer.ACS APPLIED MATERIALS & INTERFACES,12(49),54367-54377.
MLA	Guo, Pengyu,et al."Intravesical In Situ Immunostimulatory Gel for Triple Therapy of Bladder Cancer".ACS APPLIED MATERIALS & INTERFACES 12.49(2020):54367-54377.