Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography

doi:10.2147/IJN.S215648

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography
	Shi, Yujie 1; Peng, Dong 3; Wang, Dan 1; Zhao, Zongmin 2; Chen, Binlong 1; He, Bing 1; Zhu, Yukun 3; Wang, Kun 3; Tian, Jie 3; Zhang, Qiang 1
刊名	INTERNATIONAL JOURNAL OF NANOMEDICINE
	2019
卷号	14 页码:9809-9821
关键词	MSOT imaging SWCNHox exposure routes biodistribution in vivo fate
ISSN号	1178-2013
DOI	10.2147/IJN.S215648
通讯作者	Tian, Jie(tian@ieee.org) ; Zhang, Qiang(zqdodo@bjmu.edu.cn)
英文摘要	Introduction: Though widely studied for biomedical applications, the lack of current systemic studies on the in vivo fate of single-walled carbon nanohorns (SWCNHs) largely restricts their further applications, as real-time monitoring of their biodistribution remains a big challenge. Here, we aim to customize a label-free multispectral optoacoustic tomography (MSOT) method and systematically survey the fate of oxidized SWCNHs (SWCNHox) following different exposure routes by whole body imaging. Methods: Mice were given a suspension of SWCNHox with an average size of 136.4 nm via four different administration routes, and then imaged by MSOT. Results: After oral gavage, SWCNHox were mainly distributed in the gastrointestinal tract then excreted through the gut. Compared with the observation post first dosing, the accumulation of SWCNHox in the gastrointestinal tract was not obvious even after four-time oral gavage. Almost no SWCNHox were found at detectable levels in kidney, liver, blood and spleen. Following intravenous (iv) injection, SWCNHox were mainly presented and persisted in the spleen and liver, while very little in the kidney and almost none detectable in the intestine. SWCNHox accumulated significantly in the liver and spleen after four IV administrations. Following hypodermic and intramuscular injections, almost no SWCNHox could cross biological barriers and transport to the spleen, kidney or liver, likely due to their very low absorption rate. Almost all SWCNHox remained around the injection sites. For the first time, we have systematically investigated the in vivo fate of SWCNHs in a label-free and real-time manner. Conclusion: The findings of this study provide insights into the selection of appropriate exposure routes for potential biomedical applications of carbon nanomaterials.
资助项目	National Natural Science Foundation of China[81603041] ; National Basic Research Program of China (973 program)[2015CB932100]
WOS关键词	IN-VIVO ; PHOTOACOUSTIC TOMOGRAPHY ; IMAGING AGENTS ; FUNCTIONALIZATION ; TISSUE
WOS研究方向	Science & Technology - Other Topics ; Pharmacology & Pharmacy
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000502020900001
资助机构	National Natural Science Foundation of China ; National Basic Research Program of China (973 program)
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/29363]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Zhang, Qiang
作者单位	1.Peking Univ, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Sch Pharmaceut Sci, Beijing 100191, Peoples R China 2.Harvard Univ, Sch Engn & Appl Sci, Cambridge, MA 02138 USA 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Shi, Yujie,Peng, Dong,Wang, Dan,et al. Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2019,14:9809-9821.
APA	Shi, Yujie.,Peng, Dong.,Wang, Dan.,Zhao, Zongmin.,Chen, Binlong.,...&Zhang, Qiang.(2019).Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography.INTERNATIONAL JOURNAL OF NANOMEDICINE,14,9809-9821.
MLA	Shi, Yujie,et al."Biodistribution Survey of Oxidized Single-Wall Carbon Nanohorns Following Different Administration Routes by Using Label-Free Multispectral Optoacoustic Tomography".INTERNATIONAL JOURNAL OF NANOMEDICINE 14(2019):9809-9821.