Structurally diverse alkaloids produced by Aspergillus creber EN-602, an endophytic fungus obtained from the marine red alga Rhodomela confervoides | |
Li, Hong-Lei2; Yang, Sui-Qun; Li, Xiao-Ming; Li, Xin; Wang, Bin-Gui2 | |
刊名 | BIOORGANIC CHEMISTRY |
2021-05-01 | |
卷号 | 110页码:8 |
关键词 | Diketopiperazine Aspergillus creber Rhodomela confervoides Endophytic fungus ACE inhibitory activity |
ISSN号 | 0045-2068 |
DOI | 10.1016/j.bioorg.2021.104822 |
通讯作者 | Li, Hong-Lei(lihonglei@qdio.ac.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn) |
英文摘要 | Thirteen alkaloids, which include three new diketopiperazines, namely, 3-hydroxyprotuboxepin K (4), 3,15dehydroprotuboxepin K (5), and versiamide A (6), together with ten known alkaloid derivatives (1-3 and 7-13), were isolated from the marine red algal-derived fungus Aspergillus creber EN-602. Versiamide A (6) represents the first example of a naturally occurring quinazolinone alkaloid with a diketopiperazine ring that is derived from phenylalanine (Phe) and leucine (Leu). The structures of these compounds were elucidated by detailed interpretation of their 1D/2D NMR spectroscopic and mass spectrometric data, while the absolute configurations of compounds 1-6 were established on the basis of X-ray crystallographic analysis and time-dependent density functional (TDDFT) calculations of the ECD spectra. Compounds 1, 2, and 4 exhibited inhibitory activity against the angiotensin converting enzyme (ACE) with IC50 values of 11.2, 16.0, and 22.4 mu M, respectively, and compounds 5 and 6 inhibited various aquatic bacteria with MIC values that ranged from 8 to 64 mu g/mL. The intermolecular interactions and potential binding sites between compounds 1-6 and ACE were investigated via molecular docking simulations. |
资助项目 | National Natural Science Foundation of China (NSFC)[42006079] ; National Natural Science Foundation of China (NSFC)[41706182] ; Qingdao National Laboratory for Marine Science and Technology[OF2019NO03] ; Taishan Scholar Project from Shandong Province of China[ts201511060] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
WOS记录号 | WOS:000647573700007 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/170880] |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Li, Hong-Lei; Wang, Bin-Gui |
作者单位 | 1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Peoples R China 2.Chinese Acad Sci, Inst Oceanol, CAS & Shandong Prov Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Li, Hong-Lei,Yang, Sui-Qun,Li, Xiao-Ming,et al. Structurally diverse alkaloids produced by Aspergillus creber EN-602, an endophytic fungus obtained from the marine red alga Rhodomela confervoides[J]. BIOORGANIC CHEMISTRY,2021,110:8. |
APA | Li, Hong-Lei,Yang, Sui-Qun,Li, Xiao-Ming,Li, Xin,&Wang, Bin-Gui.(2021).Structurally diverse alkaloids produced by Aspergillus creber EN-602, an endophytic fungus obtained from the marine red alga Rhodomela confervoides.BIOORGANIC CHEMISTRY,110,8. |
MLA | Li, Hong-Lei,et al."Structurally diverse alkaloids produced by Aspergillus creber EN-602, an endophytic fungus obtained from the marine red alga Rhodomela confervoides".BIOORGANIC CHEMISTRY 110(2021):8. |
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