Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035

doi:10.3390/antibiotics10040377

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035
	Song, Fuhang 5; Lin, Rui 4; Yang, Na 2,3; Jia, Jia 1; Wei, Shangzhu 4; Han, Jiahui 4; Li, Jiangpeng 4; Bi, Hongkai ; Xu, Xiuli 4
刊名	ANTIBIOTICS-BASEL
	2021-04-01
卷号	10 期号:4 页码:9
关键词	marine-derived fungus Aspergillus sp natural products anti-Staphylococcus aureus anti-Helicobacter pylori
ISSN号	2079-6382
DOI	10.3390/antibiotics10040377
通讯作者	Song, Fuhang(songfuhang@btbu.edu.cn) ; Xu, Xiuli(xuxl@cugb.edu.cn)
英文摘要	Four new secondary metabolites, including one spiro[anthracenone-xanthene] derivative aspergiloxathene A (1), one penicillide analogue, Delta(2 ')-1 '-dehydropenicillide (2), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone (3) and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (4), together with four known compounds, yicathin C (5), dehydropenicillide (6), 3-methoxyepicoccone (7), 4-hydroxy-6-methoxy-5-methylphthalide (8), were identified from the marine-derived fungus Aspergillus sp. IMCASMF180035. Their structures were determined by spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) techniques. Compound 1 was identified as the first jointed molecule by xanthene and anthracenone moieties possessing an unprecedented carbon skeleton with spiro-ring system. All compounds were evaluated activities against Staphylococcus aureus, methicillin resistant S. aureus (MRSA), Escherichia coli, Escherichia faecium, Pseudomonas aeruginosa, and Helicobacter pylori. Compound 1 showed significant inhibitory effects against S. aureus and MRSA, with minimum inhibitory concentration (MIC) values of 5.60 and 22.40 mu M. Compounds 2 and 6 exhibited potent antibacterial activities against H. pylori, with MIC values of 21.73 and 21.61 mu M, respectively.
资助项目	National Key R&D Program of China[2018YFC0311000] ; Key Lab of Marine Bioactive Substance and Modern Analytical Technique, SOA[MBSMAT-2019-06] ; National Natural Science Foundation of China[81973204] ; Research Foundation for Advanced Talents of Beijing Technology and Business University[19008020158]
WOS研究方向	Infectious Diseases ; Pharmacology & Pharmacy
语种	英语
出版者	MDPI
WOS记录号	WOS:000642678600001
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/170600]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Song, Fuhang; Xu, Xiuli
作者单位	1.Nanjing Med Univ, Jiangsu Key Lab Pathogen Biol, Dept Pathogen Biol, Nanjing 211166, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.China Univ Geosci, Sch Ocean Sci, Beijing 100083, Peoples R China 5.Beijing Technol & Business Univ, Sch Light Ind, Beijing 100048, Peoples R China
推荐引用方式 GB/T 7714	Song, Fuhang,Lin, Rui,Yang, Na,et al. Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035[J]. ANTIBIOTICS-BASEL,2021,10(4):9.
APA	Song, Fuhang.,Lin, Rui.,Yang, Na.,Jia, Jia.,Wei, Shangzhu.,...&Xu, Xiuli.(2021).Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035.ANTIBIOTICS-BASEL,10(4),9.
MLA	Song, Fuhang,et al."Antibacterial Secondary Metabolites from Marine-Derived Fungus Aspergillus sp. IMCASMF180035".ANTIBIOTICS-BASEL 10.4(2021):9.