Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3 | |
Shi, Xiao-Shan3,4,5; Meng, Ling-Hong4,5; Li, Xin4,5; Wang, Dun-Jia3; Zhou, Xing-Wang3; Du, Feng-Yu1; Wang, Bin-Gui2,4,5; Li, Xiao-Ming2,4,5 | |
刊名 | CHEMISTRY & BIODIVERSITY |
2020-11-03 | |
页码 | 9 |
关键词 | Trichoderma koningiopsis Artemisia argyi polyketides terpenoids antibacterial activity |
ISSN号 | 1612-1872 |
DOI | 10.1002/cbdv.202000566 |
通讯作者 | Li, Xiao-Ming(lixmqd@qdio.ac.cn) |
英文摘要 | The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 mu g/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 mu g/mL. |
资助项目 | National Natural Science Foundation of China[31870328] ; Taishan Scholar Program from Shandong Province, China[ts201511060] |
WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry |
语种 | 英语 |
出版者 | WILEY-V C H VERLAG GMBH |
WOS记录号 | WOS:000584000700001 |
内容类型 | 期刊论文 |
源URL | [http://ir.qdio.ac.cn/handle/337002/168995] |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Li, Xiao-Ming |
作者单位 | 1.Qingdao Agr Univ, Coll Chem & Pharm, Changcheng Rd 700, Qingdao 266109, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Peoples R China 3.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China |
推荐引用方式 GB/T 7714 | Shi, Xiao-Shan,Meng, Ling-Hong,Li, Xin,et al. Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3[J]. CHEMISTRY & BIODIVERSITY,2020:9. |
APA | Shi, Xiao-Shan.,Meng, Ling-Hong.,Li, Xin.,Wang, Dun-Jia.,Zhou, Xing-Wang.,...&Li, Xiao-Ming.(2020).Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3.CHEMISTRY & BIODIVERSITY,9. |
MLA | Shi, Xiao-Shan,et al."Polyketides and Terpenoids with Potent Antibacterial Activities from the Artemisia argyi-Derived Fungus Trichoderma koningiopsis QA-3".CHEMISTRY & BIODIVERSITY (2020):9. |
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