Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress

doi:10.1038/s41598-020-63122-4

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress
	Xu, Fei 1; Gao, Tingting 1,3; Liu, Xiao 1,2
刊名	SCIENTIFIC REPORTS
	2020-04-14
卷号	10 期号:1 页码:11
ISSN号	2045-2322
DOI	10.1038/s41598-020-63122-4
英文摘要	Temperature fluctuation is a key abiotic factor for the growth and survival of Pacific abalone Haliotis discus hannai, particularly during climate change. However, the physiological mechanism underlying the abalones' response to heat stress remains unknown. We sought to understand the metabolic adaptation mechanism of Pacific abalone to heat stress for further analyzing its heat tolerance capacity. For two groups experienced different acclimate temperature (10 degrees C and 30 degrees C for 62 days), the Pacific abalone juveniles displayed significantly different survival rates under 31 degrees C acute heat treatment. A total of 1815 and 1314 differential metabolites were identified from the 10 degrees C and 30 degrees C acclimate groups respectively, by comparing mass spectrometry data of the samples before and after heat stimulation. Heat stress led to mitochondrial failure, resulting in incomplete oxidative metabolism of amino acids and fatty acids in the mitochondria, and massive accumulation of unstable metabolic intermediates in cells. The 10 degrees C acclimated group accumulated more harmful substances after heat stimulation, provoking further stress responses and pathophysiological processes. In comparison, the 30 degrees C acclimated group showed stronger regulation capacity to produce beneficial substances for metabolic homeostasis. The findings provided insight into the heat response of marine animals, especially concerning mitochondrial metabolism.
资助项目	National Natural Science Foundation of China[41776152] ; National Natural Science Foundation of China[41676152] ; Earmarked Fund for Agriculture Seed Improvement Project of Shandong Province[2017LZGC009] ; Key Deployment Project of Centre for Ocean Mega-Research of Science, Chinese Academy of Science[COMS2019Q11]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000562162800031
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/168288]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Xu, Fei
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Mega Sci, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Zhejiang Ocean Univ, Key Lab Marine Fishery Equipment & Technol Zhejia, Fishery Coll, Zhoushan 316022, Peoples R China 3.Univ Chinese Acad Sci, Beijing 10049, Peoples R China
推荐引用方式 GB/T 7714	Xu, Fei,Gao, Tingting,Liu, Xiao. Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress[J]. SCIENTIFIC REPORTS,2020,10(1):11.
APA	Xu, Fei,Gao, Tingting,&Liu, Xiao.(2020).Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress.SCIENTIFIC REPORTS,10(1),11.
MLA	Xu, Fei,et al."Metabolomics Adaptation of Juvenile Pacific Abalone Haliotis discus hannai to Heat Stress".SCIENTIFIC REPORTS 10.1(2020):11.