A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo

doi:10.1038/s41467-019-10276-z

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo
	Wang, XM ; Dai, X ; Shi, C ; Wan, JM ; Silver, MA ; Zhang, LJ ; Chen, LH ; Yi, X ; Chen, BZ ; Zhang, D
刊名	NATURE COMMUNICATIONS
	2019
卷号	10 页码:-
关键词	MULTIDENTATE CATECHOLATE SEQUESTERING AGENTS CHELATION-THERAPY EFFICACY COMPLEXES TOXICITY RATS RETENTION ACTINIDES NITRATE
ISSN号	2041-1723
DOI	10.1038/s41467-019-10276-z
文献子类	期刊论文
英文摘要	Searching for actinide decorporation agents with advantages of high decorporation efficiency, minimal biological toxicity, and high oral efficiency is crucial for nuclear safety and the sustainable development of nuclear energy. Removing actinides deposited in bones after intake is one of the most significant challenges remaining in this field because of the instantaneous formation of highly stable actinide phosphate complexes upon contact with hydroxyapatite. Here we report a hydroxypyridinone-based ligand (5LIO-1-Cm-3,2-HOPO) exhibiting stronger affinity for U(VI) compared with the reported tetradentate hydroxypyridinone ligands. This is further revealed by the first principles calculation analysis on bonding between the ligand and uranium. Both in vitro uranium removal assay and in vivo decorporation experiments with mice show that 5LIO-1-Cm-3,2-HOPO can remove uranium from kidneys and bones with high efficiencies, while the decorporation efficiency is nearly independent of the treatment time. Moreover, this ligand shows a high oral decorporation efficiency, making it attractive for practical applications.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31941]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Suzhou 215123, Peoples R China; 2.Ibm Thomas J Watson Res Ctr, Computat Biol Ctr, Yorktown Hts, NY 10598 USA; 3.Columbia Univ, Dept Chem, New York, NY 10027 USA 4.Soochow Univ, State Key Lab Radiat Med & Protect, Sch Radiol & Interdisciplinary Sci RAD X, Suzhou 215123, Peoples R China; 5.Univ Chinese Acad Sci, Shanghai Inst Appl Phys & Key Lab Nucl Radiat & N, Shanghai 201800, Peoples R China;
推荐引用方式 GB/T 7714	Wang, XM,Dai, X,Shi, C,et al. A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo[J]. NATURE COMMUNICATIONS,2019,10:-.
APA	Wang, XM.,Dai, X.,Shi, C.,Wan, JM.,Silver, MA.,...&Wang, SA.(2019).A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo.NATURE COMMUNICATIONS,10,-.
MLA	Wang, XM,et al."A 3,2-Hydroxypyridinone-based Decorporation Agent that Removes Uranium from Bones In Vivo".NATURE COMMUNICATIONS 10(2019):-.