Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis

doi:10.1016/j.phytochem.2019.112198

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis
	Li, Wen-Yuan 1,3; Liu, Yan 1; Lin, Yu-Tian 1; Liu, Yan-Chun 1; Guo, Kai 1; Li, Xiao-Nian 1; Luo, Shi-Hong 1,2; Li, Sheng-Hong 1
刊名	PHYTOCHEMISTRY
	2020-02-01
卷号	170 页码:7
关键词	Trichoderma atroviride Hypocreaceae Colquhounia coccinea var. mollis Lamiaceae Fungal endophyte Harziane diterpenoids Harzianols F-J Antibacterial activity
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.112198
通讯作者	Luo, Shi-Hong(luoshihong@syau.edu.cn) ; Li, Sheng-Hong(shli@mail.kib.ac.cn)
英文摘要	Fungal endophytes from plants are an important source for discovery of novel bioactive natural products. In this study, five undescribed harziane diterpenoids with a 4/7/5/6 tetracyclic scaffold, harzianols F-J and three known derivatives, were obtained from the liquid fermentation of an endophytic fungus Trichoderma atroviride B7, which was isolated from the healthy flower of a Lamiaceae plant Colquhounia coccinea var. mollis. Their structures were elucidated by comprehensive spectroscopic analyses and X-ray crystallographic diffraction in the case of harzianol F. Harzianol I exhibited significant antibacterial effect against the growth of Staphylococcus aureus (EC50 = 7.7 +/- 0.8 mu g/mL), Bacillus subtilis (EC50 = 7.7 +/- 1.0 mu g/mL), and Micrococcus luteus (EC50 = 9.9 +/- 1.5 mu g/mL). Meanwhile, cytotoxic activity of harzianol I against three cancer cell lines was also observed. A plausible biosynthetic pathway for harziane diterpenoids was proposed.
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000508761600018
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70485]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Luo, Shi-Hong; Li, Sheng-Hong
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Shenyang Agr Univ, Coll Biosci & Biotechnol, Shenyang 110866, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Wen-Yuan,Liu, Yan,Lin, Yu-Tian,et al. Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis[J]. PHYTOCHEMISTRY,2020,170:7.
APA	Li, Wen-Yuan.,Liu, Yan.,Lin, Yu-Tian.,Liu, Yan-Chun.,Guo, Kai.,...&Li, Sheng-Hong.(2020).Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis.PHYTOCHEMISTRY,170,7.
MLA	Li, Wen-Yuan,et al."Antibacterial harziane diterpenoids from a fungal symbiont Trichoderma atroviride isolated from Colquhounia coccinea var. mollis".PHYTOCHEMISTRY 170(2020):7.