CPNE3 moderates the association between anxiety and working memory | |
Chen, Chunhui1,2,5; Wang, Ziyi1,2,6; Chen, Chuansheng3; Xue, Gui1,2; Lu, Shuzhen1,2; Liu, Hejun1,2; Dong, Qi1,2; Zhang, Mingxia4 | |
刊名 | SCIENTIFIC REPORTS |
2021-03-25 | |
卷号 | 11期号:1页码:7 |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-021-86263-6 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | Mutual influences between anxiety and working memory (WM) have been extensively studied, and their curvilinear relationship resembles the classic Yerkes-Dodson law of arousal and performance. Given the genetic bases of both anxiety and WM, it is likely that the individual differences in the Yerkes-Dodson law of anxiety and WM may have genetic correlates. The current genome wide association study (GWAS) enrolled 1115 healthy subjects to search for genes that are potential moderators of the association between anxiety and WM. Results showed that CPNE3 rs10102229 had the strongest effect, p=3.38E-6 at SNP level and p=2.68E-06 at gene level. Anxiety and WM had a significant negative correlation (i.e., more anxious individuals performed worse on the WM tasks) for the TT genotype of rs10102229 (resulting in lower expression of CPNE3), whereas the correlation was positive (i.e., more anxious individuals performed better on the WM tasks) for the CC carriers. The same pattern of results was found at the gene level using gene score analysis. These effects were replicated in an independent sample (N=330). The current study is the first to report a gene that moderates the relation between anxiety and WM and potentially provides a genetic explanation for the classic Yerkes-Dodson law. |
资助项目 | National Natural Science Foundation of China[31571150] ; Open Research Fund of the CAS Key Laboratory of Behavioral Science, Institute of Psychology[Y5CX052003] ; 111 Project of the Ministry of Education of China[B07008] ; Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning[CNLYB1507] |
WOS研究方向 | Science & Technology - Other Topics |
出版者 | NATURE RESEARCH |
WOS记录号 | WOS:000635701800006 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38918] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Chen, Chunhui; Zhang, Mingxia |
作者单位 | 1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing, Peoples R China 2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing, Peoples R China 3.Univ Calif Irvine, Dept Psychol Sci, Irvine, CA USA 4.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 5.Beijing Normal Univ, Beijing Key Lab Brain Imaging & Connect, Beijing, Peoples R China 6.South China Normal Univ, Ctr Studies Psychol Applicat, Sch Psychol, Guangzhou, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Chunhui,Wang, Ziyi,Chen, Chuansheng,et al. CPNE3 moderates the association between anxiety and working memory[J]. SCIENTIFIC REPORTS,2021,11(1):7. |
APA | Chen, Chunhui.,Wang, Ziyi.,Chen, Chuansheng.,Xue, Gui.,Lu, Shuzhen.,...&Zhang, Mingxia.(2021).CPNE3 moderates the association between anxiety and working memory.SCIENTIFIC REPORTS,11(1),7. |
MLA | Chen, Chunhui,et al."CPNE3 moderates the association between anxiety and working memory".SCIENTIFIC REPORTS 11.1(2021):7. |
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