Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia

doi:10.1016/j.nicl.2020.102444

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	Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia
	Dietz, Martin J.1; Zhou, Yuan 2,3; Veddum, Lotte 4,5; Frith, Christopher D.6,7; Bliksted, Vibeke F.4,5,7
刊名	NEUROIMAGE-CLINICAL
	2020
卷号	28 页码:11
关键词	Schizophrenia Social cognition Brain-symptom mapping Dynamic causal modelling (DCM) Parametric empirical Bayes (PEB)
ISSN号	2213-1582
DOI	10.1016/j.nicl.2020.102444
通讯作者	Dietz, Martin J.(martin@cfin.au.dk)
英文摘要	Schizophrenia is a neurodevelopmental psychiatric disorder thought to result from synaptic dysfunction that affects distributed brain connectivity, rather than any particular brain region. While symptomatology is traditionally divided into positive and negative symptoms, abnormal social cognition is now recognized a key component of schizophrenia. Nonetheless, we are still lacking a mechanistic understanding of effective brain connectivity in schizophrenia during social cognition and how it relates to clinical symptomatology. To address this question, we used fMRI and dynamic causal modelling (DCM) to test for abnormal brain connectivity in twenty-four patients with first-episode schizophrenia (FES) compared to twenty-five matched controls performing the Human Connectome Project (HCP) social cognition paradigm. Patients had not received regular therapeutic antipsychotics, but were not completely drug naive. Whilst patients were less accurate than controls in judging social stimuli from non-social stimuli, our results revealed an increase in feedforward connectivity from motion-sensitive V5 to posterior superior temporal sulcus (pSTS) in patients compared to matched controls. At the same time, patients with a higher degree of positive symptoms had more disinhibition within pSTS, a region computationally involved in social cognition. We interpret these findings the framework of active inference, where increased feedforward connectivity may encode aberrant prediction errors from V5 to pSTS and local disinhibition within pSTS may reflect aberrant encoding of the precision of cortical representations about social stimuli.
资助项目	Interacting Minds Center, Aarhus University ; VELUX FONDEN[00013930]
WOS关键词	SOCIAL COGNITION ; MISMATCH NEGATIVITY ; SYNAPTIC PLASTICITY ; FREE-ENERGY ; BRAIN ; MIND ; METAANALYSIS ; ONSET ; TASK ; FMRI
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000600619100087
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/38171]
专题	心理研究所_中国科学院行为科学重点实验室
通讯作者	Dietz, Martin J.
作者单位	1.Aarhus Univ, Ctr Funct Integrat Neurosci, Inst Clin Med, Norrebrogade 44,01A, DK-8000 Aarhus C, Denmark 2.Inst Psychol, CAS Key Lab Behav Sci, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Dept Psychol, Beijing 100049, Peoples R China 4.Aarhus Univ Hosp, Psychosis Res Unit, Aarhus, Denmark 5.Aarhus Univ, Inst Clin Med, Aarhus, Denmark 6.UCL, Wellcome Ctr Human Neuroimaging, London, England 7.Aarhus Univ, Interacting Minds Ctr, Aarhus, Denmark
推荐引用方式 GB/T 7714	Dietz, Martin J.,Zhou, Yuan,Veddum, Lotte,et al. Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia[J]. NEUROIMAGE-CLINICAL,2020,28:11.
APA	Dietz, Martin J.,Zhou, Yuan,Veddum, Lotte,Frith, Christopher D.,&Bliksted, Vibeke F..(2020).Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia.NEUROIMAGE-CLINICAL,28,11.
MLA	Dietz, Martin J.,et al."Aberrant effective connectivity is associated with positive symptoms in first-episode schizophrenia".NEUROIMAGE-CLINICAL 28(2020):11.