A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance | |
Dong, Xinwen1,2; Li, Sa2; Kirouac, Gilbert J.2,3 | |
刊名 | NEUROBIOLOGY OF STRESS |
2020-11-01 | |
卷号 | 13页码:13 |
关键词 | Social anxiety Paraventricular nucleus of the thalamus Nucleus accumbens Dynorphin Social avoidance |
ISSN号 | 2352-2895 |
DOI | 10.1016/j.ynstr.2020.100266 |
产权排序 | 3 |
文献子类 | 实证研究 |
英文摘要 | The paraventricular nucleus of the thalamus (PVT) is an area of the dorsal midline thalamus that contributes to footshock induced anxiety. The PVT sends a dense projection to the shell of the nucleus accumbens (NAcSh) and the present study explored if this projection is involved in the behavioral changes produced by a single exposure of rats to inescapable footshocks. The inhibitory Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) hM4Di was transduced in PVT neurons that project to the NAcSh. Rats were exposed to an episode of moderately intense footshock (1.5 mA x 2 s x 5) and assigned to either high-responder (HR) or low-responder groups (LR) according to their level of fear generalization 24 h later. The effect of chemogenetic inhibition of the PVT-NAcSh projection on anxietyand fear-like behaviors was assessed at approximately 2 weeks post-footshock. HR showed a higher level of social avoidance compared to non-shocked animals and LR. The elevated level of social avoidance was attenuated in the HR treated with the hM4Di agonist clozapine (0.01 mg/kg, i.p.) or clozapine N-oxide (CNO) administrations in the NAcSh while avoidance of open spaces and contextual fear expression were not affected. Analysis of protein product of the early to immediate gene cfos indicated that these effects were mediated by dynorphin neurons in the NAcSh. This study provides evidence for a role of a projection from the PVT to the NAcSh in stress-induced social avoidance independent of anxiety to non-social stimuli and contextual fear mechanisms. |
资助项目 | Canadian Institutes of Health Research (CIHR)[MOP89758] |
WOS关键词 | POSTTRAUMATIC-STRESS ; MIDLINE THALAMUS ; BED NUCLEUS ; STRIA TERMINALIS ; AMYGDALA ; ANXIETY ; FEAR ; REWARD ; CIRCUITS ; ACTIVATION |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE INC |
WOS记录号 | WOS:000612172000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38392] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Kirouac, Gilbert J. |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China 2.Univ Manitoba, Rady Fac Hlth Sci, Dept Oral Biol, Dr Gerald Niznick Coll Dent, Winnipeg, MB R3E 0W2, Canada 3.Univ Manitoba, Rady Fac Hlth Sci, Dept Psychiat, Max Rady Coll Med, Winnipeg, MB R3E 0W2, Canada |
推荐引用方式 GB/T 7714 | Dong, Xinwen,Li, Sa,Kirouac, Gilbert J.. A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance[J]. NEUROBIOLOGY OF STRESS,2020,13:13. |
APA | Dong, Xinwen,Li, Sa,&Kirouac, Gilbert J..(2020).A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance.NEUROBIOLOGY OF STRESS,13,13. |
MLA | Dong, Xinwen,et al."A projection from the paraventricular nucleus of the thalamus to the shell of the nucleus accumbens contributes to footshock stress-induced social avoidance".NEUROBIOLOGY OF STRESS 13(2020):13. |
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