BDNF serum levels and cognitive improvement in drug-naive first episode patients with schizophrenia: A prospective 12-week longitudinal study | |
Wu, Zhi Wei1,4; Shi, Hui5; Chen, Da Chun3; Chen, Song3; Xiu, Mei Hong3; Zhang, Xiang Yang2 | |
刊名 | PSYCHONEUROENDOCRINOLOGY |
2020-12-01 | |
卷号 | 122页码:7 |
关键词 | Schizophrenia BDNF Cognitive function Risperidone Longitudinal design |
ISSN号 | 0306-4530 |
DOI | 10.1016/j.psyneuen.2020.104879 |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | Abnormal brain-derived neurotrophic factor (BDNF) levels are involved in cognitive decline in patients with schizophrenia. The role of atypical antipsychotic risperidone in improving cognitive function remains unclear. The study aimed to investigate the effect of risperidone monotherapy on cognitive impairment in drug-naive first-episode (DNFE) patients with schizophrenia and whether BDNF levels were correlated to the improvement of cognition. 354 DNFE patients and 152 healthy controls were recruited, and we compared their serum BDNF levels and cognition shown on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). High and low BDNF subgroups were defined by median split. Then, 211 patients were treated with risperidone monotherapy for 12 weeks, and their serum BDNF levels and cognition were measured again after treatment. DNFE patients had poorer cognitive functions and lower BDNF levels compared to controls. Lower BDNF levels were correlated with delayed memory in DNFE patients with high baseline BDNF levels. After 12 weeks of treatment, risperidone significantly improved immediate memory, delayed memory and RBANS total scores and BDNF levels were slightly increased. In patients with low-BDNF, BDNF levels were significantly increased after risperidone treatment, while in patients with high-BDNF, BDNF levels were significantly decreased. In addition, baseline BDNF levels were associated with improvement of delayed memory and were a prognostic factor for the improvement of the delayed memory and RBANS total score in patients with high-BDNF. Our result suggests risperidone treatment can partially improve certain domains of the cognitive impairment and baseline BDNF levels are related to cognitive response to risperidone in DNFE patients with schizophrenia. |
资助项目 | National Natural Science Foundation of China[81973759] ; National Natural Science Foundation of China[81000509] ; Chinese QiHuang Scholar Project[10400633210001] ; Shenzhen Found for Guangdong Provincial High-level Clinical Key Specialties[SZGSP013] ; Sanming Project of Medicine in Shenzhen[SZSM201812052] |
WOS研究方向 | Endocrinology & Metabolism ; Neurosciences & Neurology ; Psychiatry |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000596506500011 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38340] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Xiu, Mei Hong; Zhang, Xiang Yang |
作者单位 | 1.Shenzhen Mental Hlth Ctr, Shenzhen, Guangdong, Peoples R China 2.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 3.Peking Univ, Beijing HuiLongGuan Hosp, HuiLongGuan Clin Med Sch, Beijing, Peoples R China 4.Shenzhen Kangning Hosp, Dept Psychiat, Shenzhen, Guangdong, Peoples R China 5.Capital Med Univ, Beijing Chao Yang Hosp, Dept Clinial Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Zhi Wei,Shi, Hui,Chen, Da Chun,et al. BDNF serum levels and cognitive improvement in drug-naive first episode patients with schizophrenia: A prospective 12-week longitudinal study[J]. PSYCHONEUROENDOCRINOLOGY,2020,122:7. |
APA | Wu, Zhi Wei,Shi, Hui,Chen, Da Chun,Chen, Song,Xiu, Mei Hong,&Zhang, Xiang Yang.(2020).BDNF serum levels and cognitive improvement in drug-naive first episode patients with schizophrenia: A prospective 12-week longitudinal study.PSYCHONEUROENDOCRINOLOGY,122,7. |
MLA | Wu, Zhi Wei,et al."BDNF serum levels and cognitive improvement in drug-naive first episode patients with schizophrenia: A prospective 12-week longitudinal study".PSYCHONEUROENDOCRINOLOGY 122(2020):7. |
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