Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation | |
Man Li2,4,5; Weiwen Wang1; Lan Sun3; Wei Du3; Hao Zhou3; Feng Shao3 | |
刊名 | BEHAVIOURAL PHARMACOLOGY |
2019 | |
页码 | 9 |
关键词 | adolescent social isolation brain-derived neurotrophic factor clozapine prepulse inhibition reversal learning |
文献子类 | 实证研究 |
英文摘要 | Isolation rearing produces significant behavioral and neurochemical dysfunctions in rodents, which resemble the symptoms of schizophrenia. Clozapine, one of the atypical antipsychotics, is widely used in the treatment of schizophrenia patients and in experimental studies. In this study, male Sprague Dawley rats were randomly assigned to either group-reared or isolation-reared conditions during postnatal days (PNDs) 21–34. During PNDs 46–55, the rats weresubjected to chronicclozapine (1.0mg/kg for 10 days) or saline treatment. On PND 56, all rats underwent behavioral testing and then were sacrificed for biochemical testing. The results indicated that adolescent social isolation induced impairments in prepulse inhibition and reversal learning, and clozapine injection improved the prepulse inhibition disruption but not reversal learning ability. Furthermore, clozapine administration reversed the increased brain-derived neurotrophic factor (BDNF) mRNA level in the medial prefrontal cortex (mPFC) that was induced by adolescent isolation. However, clozapine decreased the BDNF mRNA level in the mPFC in groupreared rats. Together, our findings provide additional |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/34115] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
作者单位 | 1.Key laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China 2.Department of Psychology 3.School of Psychological and Cognitive Science, Beijing Key Laboratory of Behavior and Mental Health, Peking University 4.Center of Collaborative Innovation for Assessment and Promotion of Mental Health, Tianjin 5.Academy of Psychology and Behavior, Tianjin Normal University |
推荐引用方式 GB/T 7714 | Man Li,Weiwen Wang,Lan Sun,et al. Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation[J]. BEHAVIOURAL PHARMACOLOGY,2019:9. |
APA | Man Li,Weiwen Wang,Lan Sun,Wei Du,Hao Zhou,&Feng Shao.(2019).Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation.BEHAVIOURAL PHARMACOLOGY,9. |
MLA | Man Li,et al."Chronic clozapine treatment improves the alterations of prepulse inhibition and BDNF mRNA expression in the medial prefrontal cortex that are induced by adolescent social isolation".BEHAVIOURAL PHARMACOLOGY (2019):9. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论