Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia | |
Dong, Rui2; Yuan, Lian3; Yang, Yong4; Du, Xiang-Dong4; Jia, Qiufang4; Dillon, Brett A.1; Yu, Liling2; Zhang, Xiang Yang5,6 | |
刊名 | HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL |
2020-09-17 | |
页码 | 8 |
关键词 | clozapine cognition risperidone schizophrenia typical antipsychotic drugs |
ISSN号 | 0885-6222 |
DOI | 10.1002/hup.2754 |
产权排序 | 5 |
文献子类 | 实证研究 |
英文摘要 | Background Cognitive impairment is core feature of schizophrenia. The impact of antipsychotics on cognition remains controversial. This study aimed to examine the effects of long-term use of different types of antipsychotics on cognitive impairment in schizophrenia patients. Methods We used the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) to assess the cognition of three groups of schizophrenia patients (318 on clozapine, 125 on risperidone, and 166 on typical antipsychotic drugs) and 399 healthy controls, and used the Positive and Negative Syndrome Scale to assess schizophrenia symptoms of patients. Results Patients taking typical antipsychotics scored higher on the immediate memory and delayed memory index than those taking clozapine or risperidone (allp< 0.01). Patients taking clozapine scored higher on the language subscale than those taking risperidone (p< 0.05). Multiple regression analysis showed that the drug type was identified as an independent contributor to the immediate memory, language, and delayed memory index of RBANS (allp< 0.05). Conclusions Patients taking typical antipsychotics have better memory than those taking clozapine or risperidone. Patients taking clozapine have better language function than those taking risperidone. |
资助项目 | National Natural Science Foundation of China[81371477] ; CAS Pioneer Hundred Talents Program |
WOS关键词 | 2ND-GENERATION ANTIPSYCHOTICS ; ATYPICAL ANTIPSYCHOTICS ; ACETYLCHOLINE-RECEPTORS ; CLOZAPINE ; RISPERIDONE ; MEMORY ; HALOPERIDOL ; IMPAIRMENT ; OLANZAPINE ; IMPACT |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry ; Psychology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000571601700001 |
资助机构 | National Natural Science Foundation of China ; CAS Pioneer Hundred Talents Program |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/32868] |
专题 | 中国科学院心理研究所 |
通讯作者 | Yu, Liling; Zhang, Xiang Yang |
作者单位 | 1.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 2.Capital Med Univ, Coll Med Humanities, Dept Med Psychol, 10 Xitoutiao, Beijing, Peoples R China 3.Soochow Univ, Med Coll, Suzhou, Peoples R China 4.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China 5.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Dong, Rui,Yuan, Lian,Yang, Yong,et al. Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia[J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,2020:8. |
APA | Dong, Rui.,Yuan, Lian.,Yang, Yong.,Du, Xiang-Dong.,Jia, Qiufang.,...&Zhang, Xiang Yang.(2020).Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia.HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL,8. |
MLA | Dong, Rui,et al."Differential effects of different antipsychotic drugs on cognitive function in patients with chronic schizophrenia".HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2020):8. |
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