P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery | |
Xia, Luyao1,2; Yuan, Lian3; Du, Xiang-Dong3; Wang, Dongmei1,2; Wang, Jiesi1,2; Xu, Hang1,2; Huo, Lijuan1,2; Tian, Yang1,2; Dai, Qilong1,2; Wei, Shuochi1,2 | |
刊名 | SCHIZOPHRENIA RESEARCH |
2020 | |
卷号 | 215页码:105-112 |
关键词 | Schizophrenia Cognition P50 Sensory gating Auditory evoked potential |
ISSN号 | 0920-9964 |
DOI | 10.1016/j.schres.2019.11.012 |
产权排序 | 1 |
文献子类 | article |
英文摘要 | Objective: Cognitive impairment is a core symptom of schizophrenia (SCZ); however, its pathophysio-logical mechanisms remain unclear. The sensory gating (SG) deficits reflected by P50 inhibition are recurring in SCZ, and this inhibition may be related to the cognitive deficits seen in these individuals. This study aimed to investigate the relationship between P50 inhibition and cognitive dysfunction in SCZ, which has not been fully investigated up to this point. Methods: A total of 270 individuals with chronic SCZ and 116 healthy controls were enrolled in the study. Psychopathology of SCZ was rated by the positive and negative syndrome scale (PANSS), while cognitive function and P50 inhibition of subjects were assessed by the MATRICS Consensus Cognitive Battery (MCCB) and the electroencephalography system. Results: The MCCB total and its 10 index scores were significantly lower in patients than those in healthy controls (all p <0.001). SCZ patients had a lower amplitude of S1, and higher P50 ratio than healthy controls (both p <0.01). However, there were no significant correlations between the P50 ratio and any of the PANSS total and its subscale scores in SCZ patients (all p > 0.05). Moreover, no correlation was found between the P50 components and the MCCB scores (all p> 0.05). Conclusions: Our findings suggest that the P50 inhibition deficits occur in Chinese individuals with SCZ, which may not be associated with their clinical symptoms and cognitive impairment. (C) 2019 Elsevier B.V. All rights reserved. |
资助项目 | Science and Technology Department of Sichuan Province[2017JY0093] ; Key Diagnosis and treatment Program of Suzhou[LCZX201515] ; Key Diagnosis and treatment Program of Suzhou[LCZX201615] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
WOS关键词 | RECEPTOR SUBUNIT GENE ; VARIANTS CONFERRING RISK ; SENSORY GATING DEFICIT ; NEUROCOGNITIVE DEFICITS ; ACETYLCHOLINE-RECEPTOR ; PREPULSE INHIBITION ; CIGARETTE-SMOKING ; NICOTINIC AGONIST ; SOCIAL COGNITION ; BIPOLAR DISORDER |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000514823600016 |
资助机构 | Science and Technology Department of Sichuan Province ; Key Diagnosis and treatment Program of Suzhou ; Suzhou Key Medical Center for Psychiatric Diseases ; CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31005] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Du, Xiang-Dong; Zhang, Xiang Yang |
作者单位 | 1.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 3.Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, 11 Guangqian Rd, Suzhou 215008, Jiangsu, Peoples R China 4.Univ Texas Hlth Sci Ctr Houston, Dept Psychiat & Behav Sci, Houston, TX 77030 USA 5.Beijing HuiLongGuan Hosp, Beijing, Peoples R China 6.Fourth Peoples Hosp Chengdu, Dept Stomatol, Chengdu, Peoples R China |
推荐引用方式 GB/T 7714 | Xia, Luyao,Yuan, Lian,Du, Xiang-Dong,et al. P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery[J]. SCHIZOPHRENIA RESEARCH,2020,215:105-112. |
APA | Xia, Luyao.,Yuan, Lian.,Du, Xiang-Dong.,Wang, Dongmei.,Wang, Jiesi.,...&Zhang, Xiang Yang.(2020).P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery.SCHIZOPHRENIA RESEARCH,215,105-112. |
MLA | Xia, Luyao,et al."P50 inhibition deficit in patients with chronic schizophrenia: Relationship with cognitive impairment of MATRICS consensus cognitive battery".SCHIZOPHRENIA RESEARCH 215(2020):105-112. |
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