Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes

doi:10.1016/j.memsci.2019.117593

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes
	Liu, Yang ; Han, Qiu ; Li, Tiantain ; Hua, Jing ; Liu, Fu ; Li, Qiang ; Deng, Gang
刊名	JOURNAL OF MEMBRANE SCIENCE
	2020
卷号	595
关键词	POLYETHERSULFONE MEMBRANES ANTIFOULING PROPERTIES SURFACE MODIFICATION BLOOD COMPATIBILITY ANTICOAGULANT POLYMER HEMOCOMPATIBILITY PERFORMANCE MECHANISM CHITOSAN
DOI	10.1016/j.memsci.2019.117593
英文摘要	Heparin free prescription is highly desired for haemodialysis. Versatile strategies have been developed to address the anti-coagulation modification of dialysis membranes. We here develop a facile and effective method to construct an anticoagulant coating on polymeric membranes or a dialyzer through hydrophobic-hydrophobic interaction. An amphiphilic heparin-like copolymer was first synthesized via a free radical polymerization based on alkyl chain lauryl methacrylate (LMA), acrylic acid (AA), and sodium 4-vinylbenze-sulfonate (SSNa) segments. The specific structure of terpolymer was characterized via Fourier transform infrared spectra (FTIR), Proton nuclear magnetic resonance (H-1 NMR) spectra and size exclusion chromatography (SEC). The amphiphilic copolymer was anchored onto Polylactide (PLA) membrane surface from an aqueous-based solution via hydrophobic-hydrophobic interaction. An Attenuated total reflectance Fourier transform infrared spectra (ATR-FTIR), energy dispersive spectrometer (EDS) and X-ray photoelectron spectroscopy (XPS) confirmed the successful immobilization of heparin-mimicking terpolymers. The modified membranes showed excellent antifouling property and hydrophilicity. Moreover, the membranes exhibited outstanding haemocompatibility with suppressed platelet adhesion, low complement activation (C3a and C5a), expanded coagulation time and limited haemolysis ratio. The prolonged activated partial thromboplastin time and thrombin time (APTT>600 s, TT > 140 s) certified the excellent self-anticoagulant performances. To further examine the applicability and effectiveness, a polysulfone dialyzer was modified by this strategy. The ultrafiltration coefficient and clearance performances were examined. Overall, the hydrophobic-hydrophobic interaction strategy simplified the modification procedure of dialysis membrane, implying its great potential in heparin free dialysis application.
学科主题	Engineering ; Polymer Science
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20097]
专题	2020专题
作者单位	1.Hua, J (corresponding author), Qingdao Univ Sci & Technol, Shandong Prov Key Lab Rubber Plast, Minist Educ, Key Lab Rubber Plast, Qingdao 266042, Shandong, Peoples R China. 2.Liu, F (corresponding author), Univ Chinese Acad Sci, 19 A Yuquan Rd, Beijing 100049, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Yang,Han, Qiu,Li, Tiantain,et al. Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes[J]. JOURNAL OF MEMBRANE SCIENCE,2020,595.
APA	Liu, Yang.,Han, Qiu.,Li, Tiantain.,Hua, Jing.,Liu, Fu.,...&Deng, Gang.(2020).Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes.JOURNAL OF MEMBRANE SCIENCE,595.
MLA	Liu, Yang,et al."Heparin reduced dialysis through a facile anti-coagulant coating on flat and hollow fiber membranes".JOURNAL OF MEMBRANE SCIENCE 595(2020).