Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray

doi:10.1016/j.biopha.2020.110553

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray
	Liu, Qi 1; Li, Wenjun 1,2; Qin, Song 1,2
刊名	BIOMEDICINE & PHARMACOTHERAPY
	2020-10-01
卷号	130 页码:7
关键词	phycocyanin Radiation Oxidative stress Liver damage Nrf2/ HO-1 signaling pathway DNA damage
ISSN号	0753-3322
DOI	10.1016/j.biopha.2020.110553
通讯作者	Li, Wenjun(wjli@yic.ac.cn) ; Qin, Song(sqin@yic.an.cn)
英文摘要	1) Background: Phycocyanin (PC) is a type of natural protein in algae with antioxidant and anti-inflammatory properties. However, the protective effect of PC on hepatic damage induced by X-ray remains unknown. 2) Methods: Male C57BL/6 mice were gavaged with 200mg/kg PC for consecutive 7 days before or after radiation. The blood samples and tissues were collected on days 1 and 7 after radiation exposure. 3) Results: Pretreatment or treatment with PC decreased significantly the levels of alanine aminotransferase (ALT), aspartate aminotransferase(AST) in the plasma. Histological evaluation further confirmed the protection of PC against radiation-induced hepatotoxicity. PC-treatment also increased the relative mRNA expression of superoxide dismutase (SOD) and glutathione (GSH-PX), and descended the ROS in the liver. Moreover, the expression of H2AX, an indicator of DNA damage in mice, of the PC-intervention group was much smaller than that of the radiation group. In vivo, PC-treatment markedly up-regulated NF-E2-related factor 2(Nrf2) expression and downstream gene such as hemeoxygenase-1 (HO-1), NQO1. 4) Conclusion: PC could attenuate the radiation-induced oxidative stress damage by activating Nrf2/ HO-1 signaling pathway, and reduce the radiation-induced DNA damage. Therefore, PC is a protective agent against radiation-induced liver damage.
资助项目	National Key Research and Development Program of China[2018YFD0901102] ; Marine Economy Innovation Development Demonstration Project[YHCX-SW-P-201701] ; KeyResearch and Development Program of Yantai[2020MSGY084] ; KeyResearch and Development Program of Yantai[2019XDHZ101]
WOS关键词	SPIRULINA-PLATENSIS ; RADIATION ; INJURY ; NRF2 ; ANTIOXIDANT ; MICE ; ACTIVATION ; MODEL
WOS研究方向	Research & Experimental Medicine ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000582697900058
资助机构	National Key Research and Development Program of China ; Marine Economy Innovation Development Demonstration Project ; KeyResearch and Development Program of Yantai
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/28305]
专题	海岸带生物学与生物资源利用重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
通讯作者	Li, Wenjun; Qin, Song
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Qi,Li, Wenjun,Qin, Song. Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray[J]. BIOMEDICINE & PHARMACOTHERAPY,2020,130:7.
APA	Liu, Qi,Li, Wenjun,&Qin, Song.(2020).Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray.BIOMEDICINE & PHARMACOTHERAPY,130,7.
MLA	Liu, Qi,et al."Therapeutic effect of phycocyanin on acute liver oxidative damage caused by X-ray".BIOMEDICINE & PHARMACOTHERAPY 130(2020):7.