Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity

doi:10.1016/j.ijbiomac.2018.03.055

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity
	Chen, Yuan ; Tan, Wenqiang ; Li, Qing ; Dong, Fang ; Gu, Guodong ; Guo, Zhanyong
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2018-07-01
卷号	113 页码:1273-1278
关键词	Inulin Quaternary phosphonium salt Antifungal activity
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2018.03.055
产权排序	[Chen, Yuan ; Tan, Wenqiang ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Chen, Yuan ; Tan, Wenqiang ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
文献子类	Article
英文摘要	Inulin is a kind of renewable and biodegradable carbohydrate with good water solubility and numerous physiological functions. For further utilization of inulin, chemical modification can be applied to improve its bio-activities. In this paper, five novel inulin derivatives were synthesized via chemical modification with quaternary phosphonium salt. Their antifungal activity against three kinds of plant pathogens including Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum was assessed with radial growth assay in vitro. Results revealed that all the inulin derivatives exhibited improved antifungal activity compared with inulin. Particularly, inulin modified with triphenylphosphine (TPhPAIL) exhibited the best antifungal activity with inhibitory indices of 80.0%, 78.8%, and 87.4% against Colletotrichum lagenarium, Phomopsis asparagi, and Fusarium oxysporum at 1.0 mg/mL respectively. The results clearly showed that chemical modification of inulin with quaternary phosphonium salt could efficiently improve derivatives' antifungal activity. Further analysis of results indicated that the antifungal activity was influenced by alkyl chain length or electron-withdrawing ability of the grafted quaternary phosphonium salts. Longer alkyl chain lengths or the stronger electron-withdrawing groups would lead to enhanced antifungal efficacy.
WOS关键词	ANTIBACTERIAL ACTIVITY ; CARBOXYMETHYL CELLULOSE ; CHITOSAN ; FRUCTANS ; BIOMATERIALS ; SUBSTITUTION ; SPECTROSCOPY ; PRODUCTS ; BENEFITS ; RUBBER
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
语种	英语
WOS记录号	WOS:000432503100145
资助机构	National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Public Science and Technology Research Funds Projects of Ocean [201505022-3]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24448]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_污染过程与控制实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
推荐引用方式 GB/T 7714	Chen, Yuan,Tan, Wenqiang,Li, Qing,et al. Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2018,113:1273-1278.
APA	Chen, Yuan,Tan, Wenqiang,Li, Qing,Dong, Fang,Gu, Guodong,&Guo, Zhanyong.(2018).Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,113,1273-1278.
MLA	Chen, Yuan,et al."Synthesis of inulin derivatives with quaternary phosphonium salts and their antifungal activity".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 113(2018):1273-1278.