Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications | |
Zhang, JJ; Tan, WQ; Wei, LJ; Chen, Y; Mi, YQ; Sun, XQ; Li, Q; Dong, F; Guo, ZY | |
刊名 | CARBOHYDRATE POLYMERS |
2019-07-01 | |
卷号 | 215页码:108-118 |
关键词 | Antifungal activity Antioxidant activity Chitosan derivatives Structural characteristics Urea groups |
ISSN号 | 0144-8617 |
DOI | 10.1016/j.carbpol.2019.03.067 |
产权排序 | [Zhang, Jingjing ; Tan, Wenqiang ; Wei, Lijie ; Chen, Yuan ; Mi, Yingqi ; Sun, Xueqi ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Zhang, Jingjing ; Wei, Lijie ; Chen, Yuan ; Mi, Yingqi ; Sun, Xueqi ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
文献子类 | Article |
英文摘要 | In the current study, five novel urea-functionalized chitosan derivatives were synthesized via condensation reactions of chloroacetyl chitosan (CTCS) with urea groups bearing nitrogen-containing heterocycles. In order to identify the structure characteristics of chitosan derivatives, FT-IR, H-1 NMR spectroscopy, and elemental analysis were carried out. The antifungal activity of the derivatives against four species of phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, Fusarium oxysporum f. sp. cucumebrium Owen, and Botrytis cinerea) was evaluated. Furthermore, the antioxidant activity of chitosan derivatives was tested by hydroxyl-radical scavenging and superoxide-radical scavenging assays. The results indicated that chitosan derivatives bearing urea groups displayed superior bioactivity compared with chitosan. Besides, L929 cells were adopted for cytotoxicity test of chitosan and synthesized samples by CCK-8 assay and all samples showed decreased cytotoxicity. These results suggested that the novel urea-functionalized chitosan derivatives could be an ideal biomaterial for antifungal and antioxidant applications. |
WOS关键词 | ANTIBACTERIAL ; NANOPARTICLES ; EFFICIENCY ; HYDROGELS ; FILM |
WOS研究方向 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
语种 | 英语 |
WOS记录号 | WOS:000464112700013 |
资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese academy of sciences [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean [2015418022-3] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] |
内容类型 | 期刊论文 |
源URL | [http://ir.yic.ac.cn/handle/133337/24915] |
专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; |
推荐引用方式 GB/T 7714 | Zhang, JJ,Tan, WQ,Wei, LJ,et al. Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications[J]. CARBOHYDRATE POLYMERS,2019,215:108-118. |
APA | Zhang, JJ.,Tan, WQ.,Wei, LJ.,Chen, Y.,Mi, YQ.,...&Guo, ZY.(2019).Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications.CARBOHYDRATE POLYMERS,215,108-118. |
MLA | Zhang, JJ,et al."Synthesis of urea-functionalized chitosan derivatives for potential antifungal and antioxidant applications".CARBOHYDRATE POLYMERS 215(2019):108-118. |
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