The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice

doi:10.1007/s00253-019-10018-7

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice
	Xie, YY ; Li, WJ ; Lu, CY ; Zhu, LM ; Qin, S ; Du, ZN
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2019-10
卷号	103 期号:20 页码:8559-8569
关键词	Phycocyanin Pulmonary fibrosis Cytokines Intestinal microbiome
ISSN号	0175-7598
DOI	10.1007/s00253-019-10018-7
产权排序	[Xie, Yuanyuan ; Li, Wenjun ; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Xie, Yuanyuan ; Du, Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China ; [Xie, Yuanyuan ; Li, Wenjun ; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China ; [Lu, Chenyang] Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China ; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
文献子类	Article
英文摘要	Phycocyanin (PC) is a light-harvesting protein isolated from Spirulina and has health benefits for a range of diseases including pulmonary fibrosis (PF). In this study, a bleomycin-induced pulmonary fibrosis model was used to determine whether PC attenuates PF and modulates the intestinal microbiota. The results showed that PC intervention attenuated the pulmonary fibrosis, demonstrated by hematoxylin-eosin staining (HE), Masson's trichrome staining, and lung dry-wet weight ratio, and PC significantly inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and lipopolysaccharide (LPS). Additionally, intestinal microbiota analysis revealed that PC intervention significantly increased the bacterial diversity and richness. Correlation analysis indicated that 9 families and 17 genes were significantly associated with at least 1 physiological index. And PC intervention significantly decreased the bacteria which is related to inflammation and dramatically increased the SCFAs-producing bacteria and probiotics. These data indicated that PC can decrease the pro-inflammatory cytokines and regulate the intestinal microbiota in BLM-induced PF mice.
WOS关键词	C-PHYCOCYANIN ; HELICOBACTER-PYLORI ; ANTIOXIDANT ; SPIRULINA
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
WOS记录号	WOS:000491439700024
资助机构	National Key Research and Development Program of China [2018YFD0901102] ; Key Research and Development Program of Yantai [2019XDHZ101]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24843]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; 3.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China; 4.Ningbo Univ, Sch Marine Sci, Ningbo 315211, Zhejiang, Peoples R China; 5.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Xie, YY,Li, WJ,Lu, CY,et al. The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(20):8559-8569.
APA	Xie, YY,Li, WJ,Lu, CY,Zhu, LM,Qin, S,&Du, ZN.(2019).The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(20),8559-8569.
MLA	Xie, YY,et al."The effects of phycocyanin on bleomycin-induced pulmonary fibrosis and the intestinal microbiota in C57BL/6 mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.20(2019):8559-8569.