Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach

doi:10.1016/j.envpol.2019.113333

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach
	Xu, LL ; Lu, Z ; Ji, CL ; Cong, M ; Li, F ; Shan, XJ ; Wu, HF
刊名	ENVIRONMENTAL POLLUTION
	2019-12
卷号	255 期号:2 页码:113333
关键词	Arsenic Toxicological effect Juvenile rockfish Proteomics Metabolomics
ISSN号	0269-7491
DOI	10.1016/j.envpol.2019.113333
产权排序	[Xu, Lanlan ; Lu, Zhen ; Ji, Chenglong ; Cong, Ming ; Li, Fei ; Wu, Huifeng] Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China ; [Ji, Chenglong ; Shan, Xiujuan ; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China ; [Xu, Lanlan ; Lu, Zhen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	Arsenic (As) is a metalloid element that is ubiquitous in the marine environment and its contamination has received worldwide attention due to its potential toxicity. Arsenic can induce multiple adverse effects, such as lipid metabolism disorder, immune system dysfunction, oxidative stress and carcinogenesis, in animals. Inorganic arsenic includes two chemical forms, arsenite (As (III)) and arsenate (As (V)), in natural environment. As (V) is the dominant form in natural waters. In the present study, metabolomic and proteomic alterations were investigated in juvenile rockfish Sebastes schlegelii exposed to environmentally relevant concentrations of As (V) for 14 d. The analysis of iTRAQ-based proteomics combined with untargeted NMR-based metabolomics indicated apparent toxicological effects induced by As (V) in juvenile rockfish. In details, the metabolites, including lactate, alanine, ATP, inosine and phosphocholine were significantly altered in As-treated groups. Proteomic responses suggested that As (V) could not only affected energy and primary metabolisms and signal transduction, but also influenced cytoskeleton structure in juvenile rockfish. This work suggested that the combined proteomic and metabolomic approach could shed light on the toxicological effects of pollutants in rockfish S. schlegelii. (C) 2019 Elsevier Ltd. All rights reserved.
WOS关键词	CLAM RUDITAPES-PHILIPPINARUM ; FISH LIZA-AURATA ; CASEIN KINASE-I ; OXIDATIVE STRESS ; MYTILUS-GALLOPROVINCIALIS ; ARSENIC EXPOSURE ; HEAVY-METALS ; RESPONSES ; MECHANISMS ; MERCURY
WOS研究方向	Environmental Sciences
语种	英语
WOS记录号	WOS:000498340400088
资助机构	NSFCNational Natural Science Foundation of China [41676114] ; Young Taishan Scholars Program of Shandong Province [tsqn201812115] ; Qingdao National Laboratory for Marine Science and Technology [QNLM201701] ; Youth Innovation Promotion Association CAS [2015169]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24807]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_近岸生态与环境实验室
作者单位	1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shandong Key Lab Coastal Environm Proc, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC,YICCAS, Yantai 264003, Peoples R China;
推荐引用方式 GB/T 7714	Xu, LL,Lu, Z,Ji, CL,et al. Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach[J]. ENVIRONMENTAL POLLUTION,2019,255(2):113333.
APA	Xu, LL.,Lu, Z.,Ji, CL.,Cong, M.,Li, F.,...&Wu, HF.(2019).Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach.ENVIRONMENTAL POLLUTION,255(2),113333.
MLA	Xu, LL,et al."Toxicological effects of As (V) in juvenile rockfish Sebastes schlegelii by a combined metabolomic and proteomic approach".ENVIRONMENTAL POLLUTION 255.2(2019):113333.