Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

doi:10.1016/j.bios.2018.04.028

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室 > 近岸生态与环境实验室

	Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis
	Yang, Qian ; Li, Jinhua ; Wang, Xiaoyan ; Peng, Hailong ; Xiong, Hua ; Chen, Lingxin
刊名	BIOSENSORS & BIOELECTRONICS
	2018-07-30
卷号	112 页码:54-71
关键词	Molecular imprinting Sensor Fluorescent detection Construction strategy Microdevice
ISSN号	0956-5663
DOI	10.1016/j.bios.2018.04.028
产权排序	[Yang, Qian ; Peng, Hailong ; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China ; [Yang, Qian ; Li, Jinhua ; Wang, Xiaoyan ; Chen, Lingxin] Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Yang, Qian ; Li, Jinhua ; Wang, Xiaoyan ; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Yantai 264003, Peoples R China ; [Wang, Xiaoyan] Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
文献子类	Article
英文摘要	One pressing concern today is to construct sensors that can withstand various disturbances for highly selective and sensitive detecting trace analytes in complicated samples. Molecularly imprinted polymers (MIPs) with tailor-made binding sites are preferred to be recognition elements in sensors for effective targets detection, and fluorescence measurement assists in highly sensitive detection and user-friendly control. Accordingly, molecular imprinting-based fluorescence sensors (MI-FL sensors) have attracted great research interest in many fields such as chemical and biological analysis. Herein, we comprehensively review the recent advances in MI-FL sensors construction and applications, giving insights on sensing principles and signal transduction mechanisms, focusing on general construction strategies for intrinsically fluorescent or nonfluorescent analytes and improvement strategies in sensing performance, particularly in sensitivity. Construction strategies are well overviewed, mainly including the traditional indirect methods of competitive binding against pre-bound fluorescent indicators, employment of fluorescent functional monomers and embedding of fluorescence substances, and novel rational designs of hierarchical architecture (core-shell/hollow and mesoporous structures), post-imprinting modification, and ratiometric fluorescence detection. Furthermore, MI-FL sensor based microdevices are discussed, involving micromotors, test strips and microfluidics, which are more portable for rapid point-of-care detection and in-field diagnosing. Finally, the current challenges and future perspectives of MI-FL sensors are proposed.
WOS关键词	GRAPHENE QUANTUM DOTS ; METAL-ORGANIC FRAMEWORKS ; CORE-SHELL PARTICLES ; ONE-POT SYNTHESIS ; UP-CONVERSION ; RATIOMETRIC FLUORESCENCE ; SENSITIVE DETECTION ; SELECTIVE DETECTION ; BISPHENOL-A ; POLYMER NANOPARTICLES
WOS研究方向	Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
语种	英语
WOS记录号	WOS:000433648000008
资助机构	National Natural Science Foundation of China [21667018, 21477160, 31660482, 41776110, 21575159] ; Natural Science Foundation of Shandong Province of China [ZR2016BL25]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24433]
专题	烟台海岸带研究所_近岸生态与环境实验室烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China; 2.Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res Ctr Coastal Environm Engn & Technol, Yantai 264003, Peoples R China; 4.Binzhou Med Univ, Sch Pharm, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Yang, Qian,Li, Jinhua,Wang, Xiaoyan,et al. Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis[J]. BIOSENSORS & BIOELECTRONICS,2018,112:54-71.
APA	Yang, Qian,Li, Jinhua,Wang, Xiaoyan,Peng, Hailong,Xiong, Hua,&Chen, Lingxin.(2018).Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis.BIOSENSORS & BIOELECTRONICS,112,54-71.
MLA	Yang, Qian,et al."Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis".BIOSENSORS & BIOELECTRONICS 112(2018):54-71.