A novel terahertz nanofilm sensor consisting of toroidal dipole bound states in the continuum (TD-BIC) inspired Fano resonance metasurface is proposed and investigated, which exhibits both the TD character and BIC feature. When the mirror symmetry of the unit cell was broken, the TD resonance was excited and demonstrated by anti-aligned magnetic dipoles and calculated scattering powers and the BIC mode was verified with the quality factor satisfying the inverse square law. Combined with the amplitude difference referencing technique, the TD-BIC inspired Fano resonance was utilized for nanofilm sensing at THz frequencies for the first time. Simulation results show that the amplitude difference can be easily observed by comparing the resonance frequency shift under difference thicknesses of germanium overlayer. Moreover, by coating with a 40 nm-thick analyte overlayer, the sensitivity of amplitude difference can achieve 0.32/RIU, which is a significant value and more suitable for sensing nanofilm analytes than the traditional frequency shift method. These advantages make our proposed structure have potential applications in sensing nanofilm analytes. © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement