Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics

doi:10.1021/acsami.0c09952

CORC > 合肥物质科学研究院 > 中国科学院合肥物质科学研究院 > 中科院固体物理研究所

	Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics
	Xu, Rui 1,2,3; Xu, Zhaowei 2; Si, Yuanchun 1; Xing, Xin 1; Li, Qingdong 2,4; Xiao, Jianmin 4; Wang, Bin 2; Tian, Geng 2; Zhu, Ling 3; Wu, Zhengyan 4
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-08-19
卷号	12
关键词	oxygen vacancy defects nanotheranostic agent catalytic activity MRI contrast enhancement oxygen self-supplement
ISSN号	1944-8244
DOI	10.1021/acsami.0c09952
通讯作者	Zhu, Ling(zhuling1425@163.com) ; Wu, Zhengyan(zywu@ipp.ac.cn) ; Zhang, Guilong(glzhang@bzmc.edu.cn)
英文摘要	This work finds that Fe3O4 nanoclusters can rearrange by Gd doping and then self-assemble to a hollow magnetic nanocluster (HMNC), providing larger magnetic moments to obtain an excellent MRI capability and increasing the number of oxygen vacancies in HMNC. The hollow structure makes platinum(IV) prodrugs effectively load into HIVING. Second, plenty of oxygen vacancy defects can capture oxygen molecules, enhance the catalytic activity of HMNC, and then promote intracellular ROS generation. On the basis of this, a targeting iRGD-labeled HMNC nanosystem (iHMNCPt-O-2) is developed through loading oxygen molecules and platinum(IV) prodrugs for chemo- and chemodynamic therapy of cancer. This nanosystem shows an excellent response ability to weak acid and GSH, which can cause a series of cascade reactions in a cell. These cascade reactions are dramatically enhanced at the intracellular ROS level, cause mitochondria and DNA damage, and then induce cancer cell death. Besides, systemic delivery of iHMNCPt-O-2 significantly enhanced the MRI contrast signal of tumors and improved the quality of MR images, accurately diagnosing tumors. Therefore, this work provides a novel method for accelerating the Fenton-like reaction and enhancing the MRI capability and fabricates a promising "all-in-one" system to overwhelm the problems of cancer theranostic.
资助项目	Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; Natural Science Foundation of Anhui Province[1808085MB38] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; National Natural Science Foundation of China[81630019] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
WOS关键词	OVERCOME MULTIDRUG-RESISTANCE ; FENTON-LIKE DEGRADATION ; CHEMOTHERAPY ; GLUTATHIONE ; GENERATION ; MICROENVIRONMENT ; NANOPARTICLES ; THERAPY ; DAMAGE
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000563074900010
资助机构	Taishan Scholars Construction Engineering ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/43057]
专题	合肥物质科学研究院_中科院固体物理研究所
通讯作者	Zhu, Ling; Wu, Zhengyan; Zhang, Guilong
作者单位	1.Anhui Med Univ, Dept Dent Implant Ctr, Stomatol Hosp & Coll, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China 2.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai 264003, Peoples R China 3.Shanghai Jiao Tong Univ, Sch Med, Dept Radiol, Shanghai Peoples Hosp 9, Shanghai 200001, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Xu, Rui,Xu, Zhaowei,Si, Yuanchun,et al. Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12.
APA	Xu, Rui.,Xu, Zhaowei.,Si, Yuanchun.,Xing, Xin.,Li, Qingdong.,...&Zhang, Guilong.(2020).Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics.ACS APPLIED MATERIALS & INTERFACES,12.
MLA	Xu, Rui,et al."Oxygen Vacancy Defect-Induced Activity Enhancement of Gd Doping Magnetic Nanocluster for Oxygen Supplying Cancer Theranostics".ACS APPLIED MATERIALS & INTERFACES 12(2020).