EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer's disease: a prospective cohort study

doi:10.21037/atm-20-6647

	EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer's disease: a prospective cohort study
	Liao, Zhengluan 4; Zhao, Xiaoyu 5; Li, Ting 6; Mao, Yanping 7; Hu, Jiaojiao 7; Le, Dansheng 1; Pei, Yangliu 3; Chen, Yan 4; Qiu, Yaju 4; Zhu, Junpeng 4
刊名	ANNALS OF TRANSLATIONAL MEDICINE
	2021
卷号	9
关键词	Alzheimer's disease (AD) anxiety tandospirone citrate EEG power spectrum
ISSN号	2305-5839
DOI	10.21037/atm-20-6647
通讯作者	Yu, Enyan(yuenyan@aliyun.com)
英文摘要	Background: To study the efficacy of tandospirone citrate in treating Alzheimer's disease (AD) patients with anxiety. Methods: Thirty mild-to-moderate AD patients with anxiety symptoms were randomly divided into a monotherapy group (donepezil) and a combination therapy group (donepezil and tandospirone). The treatment lasted for 12 weeks. Drug efficacy was regularly assessed using psychological assessment scales and quantitative pharmaco-electroencephalogram (QPEEG) power spectral analysis. Results: After 12 weeks of treatment, the mean Hamilton Anxiety Scale (HAMA) score and mean Neuropsychiatric Inventory (NPI) score of the combination therapy group were 5.13 +/- 4.18 and 4.2 +/- 5.0, respectively, which was significantly lower compared to baseline and the monotherapy group (all P<0.05). The mean attention score on the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-Cog) was 0.07 +/- 0.26 for the combination group, which was significantly lower than that of the monotherapy group (P<0.05). QPEEG revealed that the power values of the delta wave in the right prefrontal lobe, left middle temporal lobe and right posterior temporal lobe decreased in the combination therapy group but not in the monotherapy group. Similarly, the power values of the alpha 2 wave in the right parietal, right posterior temporal and left middle temporal lobes, and the beta 1 wave power values of left middle temporal and left posterior temporal lobes were also significantly decreased in the combination therapy group, but not in the monotherapy group. Conclusions: Tandospirone citrate can significantly improve anxiety symptoms and attention in patients with mild to moderate AD. QPEEG examination might provide a objective way for the efficacy of the tandospirone in anxiety symptoms of the patients with Alzheimer's disease.
资助项目	Natural Science Foundation of China[Wcpafund-201508] ; Science Foundation of the Health Commission of Zhejiang Province[81771158] ; Sumitomo Dainippon Pharma Co., Ltd (Suzhou, China)[2019321345] ; [SED-AD-2016-001]
WOS研究方向	Oncology ; Research & Experimental Medicine
语种	英语
出版者	AME PUBL CO
WOS记录号	WOS:000640889600041
资助机构	Natural Science Foundation of China ; Science Foundation of the Health Commission of Zhejiang Province ; Sumitomo Dainippon Pharma Co., Ltd (Suzhou, China)
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/122017]
专题	中国科学院合肥物质科学研究院
通讯作者	Yu, Enyan
作者单位	1.Zhejiang Chinese Med Univ, Hangzhou, Peoples R China 2.Shengsi Cty Peoples Hosp, Dept Internal Med, Zhoushan, Peoples R China 3.Bengbu Med Coll, Bengbu, Peoples R China 4.Zhejiang Prov Peoples Hosp, Dept Psychiat, Hangzhou, Peoples R China 5.Zhejiang Prov Peoples Hosp, Dept Elect Sci, Hangzhou, Peoples R China 6.Qingdao Univ, Med Dept, Qingdao, Peoples R China 7.Univ Chinese Acad Sci, Zhejiang Canc Hosp, Dept Psychol Med, Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Liao, Zhengluan,Zhao, Xiaoyu,Li, Ting,et al. EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer's disease: a prospective cohort study[J]. ANNALS OF TRANSLATIONAL MEDICINE,2021,9.
APA	Liao, Zhengluan.,Zhao, Xiaoyu.,Li, Ting.,Mao, Yanping.,Hu, Jiaojiao.,...&Yu, Enyan.(2021).EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer's disease: a prospective cohort study.ANNALS OF TRANSLATIONAL MEDICINE,9.
MLA	Liao, Zhengluan,et al."EEG power spectral analysis reveals tandospirone improves anxiety symptoms in patients with Alzheimer's disease: a prospective cohort study".ANNALS OF TRANSLATIONAL MEDICINE 9(2021).