Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications

doi:10.1016/j.matt.2020.11.002

	Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications
	Huang, Zike 1,2; Qiu, Liping 2; Zhang, Tao 1,3; Tan, Weihong 1,2
刊名	MATTER
	2021-02-03
卷号	4
ISSN号	2590-2393
DOI	10.1016/j.matt.2020.11.002
通讯作者	Zhang, Tao(zhtao@zju.edu.cn) ; Tan, Weihong(tan@hnu.edu.cn)
英文摘要	In addition to critical biological roles, DNA is also considered an excellent engineering material with unique characteristics of high programmability and addressability. Recent advances in DNA nano technology enable the rational design and precise fabrication of various exquisite DNA nanostructures, providing many new opportunities for technological uses. Meanwhile, the integration of DNA nanostructures with molecular recognition capacity can further expand the scope of their application. Particularly suited to this goal, aptamers are short single-stranded nucleic acids selected via an in vitro strategy called systematic evolution of ligands by exponential enrichment. As analogs to antibodies, aptamers can bind to various targets, such as small molecules, proteins, viruses, bacteria, and even whole cells. Apart from comparable specificity and affinity as antibodies, aptamers have several advantages, including small molecular weight, high designability, easy synthesis, and convenient modification. Indeed, the marriage of aptamers with DNA nanostructures has generated many powerful tools for advanced biological and biomedical applications. In this review, we summarize the recent progress, application, and prospect of aptamer-integrated DNA nanotechnology in the fields of biosensing, bioimaging, targeted drug delivery, bioregulation, and biomimicry.
资助项目	National Natural Science Foundation of China[21827811] ; National Natural Science Foundation of China[91753109] ; National Natural Science Foundation of China[21922404] ; National Natural Science Foundation of China[21904118] ; National Natural Science Foundation of China[21275129] ; National Natural Science Foundation of China[61527806] ; National Key Research Program[2019YFA0905800] ; National Key Research Program[2018YFC1602900] ; Natural Science Foundation of Zhejiang Province[LY19B050006] ; Natural Science Foundation of Zhejiang Province[LY17B050008] ; State Key Laboratory of Industrial Control Technology[ICT1914]
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000632645300008
资助机构	National Natural Science Foundation of China ; National Key Research Program ; Natural Science Foundation of Zhejiang Province ; State Key Laboratory of Industrial Control Technology
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121780]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Tao; Tan, Weihong
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Basic Med & Canc IBMC, Canc Hosp, Hangzhou 310022, Zhejiang, Peoples R China 2.Hunan Univ, Coll Chem & Chem Engn, Coll Biol, Mol Sci & Biomed Lab MBL,State Key Lab Chemo Bios, Changsha 410082, Peoples R China 3.Zhejiang Univ, Coll Control Sci & Engn, Res Ctr Analyt Instrumentat, Inst Intelligent Control & Syst,State Key Lab Ind, Hangzhou 310027, Peoples R China
推荐引用方式 GB/T 7714	Huang, Zike,Qiu, Liping,Zhang, Tao,et al. Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications[J]. MATTER,2021,4.
APA	Huang, Zike,Qiu, Liping,Zhang, Tao,&Tan, Weihong.(2021).Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications.MATTER,4.
MLA	Huang, Zike,et al."Integrating DNA Nanotechnology with Aptamers for Biological and Biomedical Applications".MATTER 4(2021).