Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally

doi:10.1038/s41598-020-79569-4

	Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally
	Chen, Wei 3; Geng, Jia 1; Tan, Ya-lan 2; Zhao, Lian 3; Jia, Hui-hui 3; Guo, Wan-liang 3
刊名	SCIENTIFIC REPORTS
	2021-01-08
卷号	11
ISSN号	2045-2322
DOI	10.1038/s41598-020-79569-4
通讯作者	Guo, Wan-liang(gwlsuzhou@163.com)
英文摘要	The general condition, clinical and pathological characteristics, and treatment regimens of patients prenatally and postnatally diagnosed with congenital choledochal malformation (CM) were analyzed in order to investigate the clinical significance of early diagnosis, treatment, and intervention in CM. We retrospectively analyzed 33 children who were admitted to the Children's Hospital of Soochow University between 1 March 2010 and 31 May 2019, and their diagnosis of CM was confirmed by radiological, surgical and pathological findings. All the patients were under 36 months of age. The patients were divided into prenatally diagnosed and postnatally diagnosed groups. There were 16 and 17 CM patients in the prenatally and postnatally diagnosed groups, respectively, with a preponderance of females in both groups. Compared with the prenatally diagnosed group, the postnatally diagnosed group had a higher incidence of abdominal pain and vomiting (p<0.05) and higher AST, GGT, and TB levels (p<0.05). Although postoperative histopathological examination showed inflammation in both groups, congestion in the cyst walls and fibrous tissue hyperplasia were more significant in the postnatally diagnosed group (p<0.05). In addition, operation time, length of time required to resume a normal diet after surgery, and total length of hospitalization differed between the 2 groups (p<0.05), with the prenatally diagnosed group having a relatively longer operation time and taking longer to resume a normal diet after surgery. However, the total length of hospitalization in the prenatally diagnosed group was shorter than that in the postnatally diagnosed group. Compared with prenatally diagnosed CM patients, more symptoms, greater severity of symptoms, and more time to recovery after surgery were observed in postnatally diagnosed CM patients.
资助项目	National Natural Science Foundation[81971685] ; Science and Technology Project of Suzhou[SS201868]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000634374700012
资助机构	National Natural Science Foundation ; Science and Technology Project of Suzhou
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121337]
专题	中国科学院合肥物质科学研究院
通讯作者	Guo, Wan-liang
作者单位	1.3rd Hosp Yulin City, Clin Lab, Yulin 719000, Peoples R China 2.Univ Chinese Acad Sci, Dept Radiol, Canc Hosp, Hangzhou, Peoples R China 3.Soochow Univ, Dept Radiol, Childrens Hosp, Suzhou 215025, Peoples R China
推荐引用方式 GB/T 7714	Chen, Wei,Geng, Jia,Tan, Ya-lan,et al. Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally[J]. SCIENTIFIC REPORTS,2021,11.
APA	Chen, Wei,Geng, Jia,Tan, Ya-lan,Zhao, Lian,Jia, Hui-hui,&Guo, Wan-liang.(2021).Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally.SCIENTIFIC REPORTS,11.
MLA	Chen, Wei,et al."Different characteristics of infants diagnosed with congenital choledochal malformation prenatally or postnatally".SCIENTIFIC REPORTS 11(2021).