Immunological impact of chemotherapy on the tumor microenvironment in gastric cancer

doi:10.1002/jso.26449

	Immunological impact of chemotherapy on the tumor microenvironment in gastric cancer
	Wei, Qing 1,2; Xu, Qi 1,2; Yuan, Xing 1,2; Li, Jing-Jing 1,2; Chen, Lei 1,2; Luo, Cong 1,2; Zhu, Xiu 2,3; Ying, Jie-Er 1,2
刊名	JOURNAL OF SURGICAL ONCOLOGY
	2021-03-08
关键词	chemotherapy gastric cancer tumor‐ associated macrophage tumor‐ infiltrating lymphocytes
ISSN号	0022-4790
DOI	10.1002/jso.26449
通讯作者	Zhu, Xiu(15868870650@163.com) ; Ying, Jie-Er(jieerying@aliyun.com)
英文摘要	Objective This study aimed to investigate alterations in pre- and post-neoadjuvant chemotherapy (NACT) tumor-infiltrating immune cells and subsequent evaluation of the predictive and prognostic value of these changes in gastric cancer (GC). Methods Fifty patients with GC underwent three cycles of S-1 and oxaliplatin (SOX regimen)-NACT. Paired samples from tumor lesions before and after NACT were available for all patients participating in the study. Immunohistochemistry was performed for T cell subsets (CD3(+) and CD8(+)) and macrophages (CD68(+) and CD163(+)). Results After NACT, the average expression levels of CD3, CD8, CD68, and CD163 were significantly increased (p < .001). However, neither expression levels pre- nor post-chemotherapy correlated with treatment response. Multivariate Cox regression analysis demonstrated that upregulation of CD8/CD3 levels (hazard ratio [HR] = 0.117; 95% confidence interval [CI] = 0.031-0.446; p = 0.002) and CD163 levels after chemotherapy (HR = 2.258; 95% CI = 1.047-4.867; p = 0.038) were independent prognostic factors of overall survival. Conclusion Chemotherapy in GC is useful to induce CD3(+) and CD8(+) T lymphocytes as well as CD68(+) and CD163(+) macrophages in the tumor microenvironment in combination with its direct cytotoxic effects. These results indicate that chemotherapy may play a role in tumor immune microenvironment remodeling.
资助项目	Zhejiang Natural Science Foundation[LQ21H160005]
WOS研究方向	Oncology ; Surgery
语种	英语
出版者	WILEY
WOS记录号	WOS:000626187700001
资助机构	Zhejiang Natural Science Foundation
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121095]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhu, Xiu; Ying, Jie-Er
作者单位	1.Univ Chinese Acad Sci, Canc Hosp, Dept Med Oncol, Zhejiang Canc Hosp, Hangzhou, Peoples R China 2.Chinese Acad Sci, Inst Canc & Basic Med, Hangzhou, Peoples R China 3.Univ Chinese Acad Sci, Dept Pathol, Canc Hosp, Zhejiang Canc Hosp, Hangzhou, Peoples R China
推荐引用方式 GB/T 7714	Wei, Qing,Xu, Qi,Yuan, Xing,et al. Immunological impact of chemotherapy on the tumor microenvironment in gastric cancer[J]. JOURNAL OF SURGICAL ONCOLOGY,2021.
APA	Wei, Qing.,Xu, Qi.,Yuan, Xing.,Li, Jing-Jing.,Chen, Lei.,...&Ying, Jie-Er.(2021).Immunological impact of chemotherapy on the tumor microenvironment in gastric cancer.JOURNAL OF SURGICAL ONCOLOGY.
MLA	Wei, Qing,et al."Immunological impact of chemotherapy on the tumor microenvironment in gastric cancer".JOURNAL OF SURGICAL ONCOLOGY (2021).