CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy

doi:10.1039/d0mh01685c

	CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy
	Zhang, Guilong 1; Xie, Wenteng 2; Xu, Zhaowei 1; Si, Yuanchun 3; Li, Qingdong 1; Qi, Xiangyu 1; Gan, Yuehao 2; Wu, Zhengyan 2; Tian, Geng 1
刊名	MATERIALS HORIZONS
	2021-03-01
卷号	8
ISSN号	2051-6347
DOI	10.1039/d0mh01685c
通讯作者	Zhang, Guilong(glzhang@bzmc.edu.cn) ; Wu, Zhengyan(zywu@ipp.ac.cn) ; Tian, Geng(tiangengbmu@163.com)
英文摘要	Theoretically, the Fenton catalytic efficiency of the Cu-based nanoplatform is approximately 160 times that of traditional Fe-based agents. However, the coordination interaction between Cu(ii) and intracellular GSH significantly inhibits the high catalytic activity of Cu(i) generation, dramatically decreasing the Fenton-like catalytic efficiency. Herein, we designed a completely new and highly efficient hierarchical structural nanoplatform to enhance the mimic-peroxidase activity through utilizing comproportionation between CuO and elemental Cu core to self-supply Cu(i). The catalytic rate of this nanoplatform was approximately 55-fold that of traditional Fe-based agents. In a cell assay, this nanoplatform could function as an antagonist of GPX4 and agonist of SOD-1, resulting in intracellular ROS and H2O2 accumulation. Next, the accumulated H2O2 could be quickly catalyzed to highly toxic OH by self-supplying Cu(i), causing strong oxidative stress damage to mitochondria and cell membranes. Under 808 nm laser irradiation, this nanoplatform exhibited a stronger inhibition of tumor growth, and effectively overcame the tumor resistance and recurrence. In addition, this hierarchical structure significantly promoted the interaction between water molecules and gadolinium centers, making TRF-mCuGd possess an ultrahigh T-1 MRI contrast performance, and hence, more pathological information of the tumor could be achieved. Overall, this work provides a promising pattern for the design and development of cancer theranostics.
资助项目	Taishan Scholars Construction Engineering[tsqn20161047] ; Taishan Scholars Construction Engineering[tsqn201909144] ; National Natural Science Foundation of China[22007006] ; National Natural Science Foundation of China[31771284] ; National Natural Science Foundation of China[81401518] ; National Natural Science Foundation of China[31430028] ; National Natural Science Foundation of China[81630019] ; Special Project of Central Government for Local Science and Technology Development of Shandong Province[YDZX20203700001291] ; Natural Science Foundation of Anhui Province[1808085MB38] ; Shandong Provincial Natural Science Foundation[ZR2016JL026] ; Key Research and Development Plan of Shandong Province[2018GSF118230]
WOS研究方向	Chemistry ; Materials Science
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000632017700019
资助机构	Taishan Scholars Construction Engineering ; National Natural Science Foundation of China ; Special Project of Central Government for Local Science and Technology Development of Shandong Province ; Natural Science Foundation of Anhui Province ; Shandong Provincial Natural Science Foundation ; Key Research and Development Plan of Shandong Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/121089]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Guilong; Wu, Zhengyan; Tian, Geng
作者单位	1.Binzhou Med Univ, Sch Pharm, Key Lab Prescript Effect & Clin Evaluat State Adm, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China 3.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Guilong,Xie, Wenteng,Xu, Zhaowei,et al. CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy[J]. MATERIALS HORIZONS,2021,8.
APA	Zhang, Guilong.,Xie, Wenteng.,Xu, Zhaowei.,Si, Yuanchun.,Li, Qingdong.,...&Tian, Geng.(2021).CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy.MATERIALS HORIZONS,8.
MLA	Zhang, Guilong,et al."CuO dot-decorated Cu@Gd2O3 core-shell hierarchical structure for Cu(i) self-supplying chemodynamic therapy in combination with MRI-guided photothermal synergistic therapy".MATERIALS HORIZONS 8(2021).