Progress on treatment of MET signaling pathway in non-small cell lung cancer

doi:10.1007/s10147-020-01702-0

	Progress on treatment of MET signaling pathway in non-small cell lung cancer
	Yu, Xiaoqing 1,2,3; Yu, Sizhe 2,3; Fan, Yun 1,2,3
刊名	INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
	2020-05-21
关键词	MET Dysregulation Overexpression Amplification Non-small cell lung cancer
ISSN号	1341-9625
DOI	10.1007/s10147-020-01702-0
通讯作者	Fan, Yun(fanyun_zicc@163.com)
英文摘要	MET activation includes gene mutation, amplification, and protein overexpression. Clinical evidence suggests that MET activation is both a primary oncogenic driver in lung cancer, and a secondary driver after acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Several small molecule TKIs have already shown to be effective in the MET pathway. However, the activation form and the diagnostic criteria of MET oncogene are still controversial, especially in patients resistant to EGFR TKIs or ALK TKIs. With the development of new MET inhibitors, a quantity of emerging trials has focused on the mechanism of acquired resistance to MET TKIs and therapeutic strategies after resistance.
WOS关键词	TYROSINE KINASE INHIBITORS ; TIVANTINIB ARQ 197 ; EGFR-MUTANT NSCLC ; EXON 14 MUTATIONS ; ACQUIRED-RESISTANCE ; PLUS ERLOTINIB ; DOUBLE-BLIND ; PHASE-II ; AMPLIFICATION ; GROWTH
WOS研究方向	Oncology
语种	英语
出版者	SPRINGER JAPAN KK
WOS记录号	WOS:000534831100001
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/103175]
专题	中国科学院合肥物质科学研究院
通讯作者	Fan, Yun
作者单位	1.Chinese Acad Sci, Inst Canc & Basic Med ICBM, Hangzhou, Peoples R China 2.Univ Chinese Acad Sci, Canc Hosp, Dept Med Oncol, Hangzhou, Peoples R China 3.Zhejiang Canc Hosp, Dept Med Oncol, 1 Banshandong Rd, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yu, Xiaoqing,Yu, Sizhe,Fan, Yun. Progress on treatment of MET signaling pathway in non-small cell lung cancer[J]. INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY,2020.
APA	Yu, Xiaoqing,Yu, Sizhe,&Fan, Yun.(2020).Progress on treatment of MET signaling pathway in non-small cell lung cancer.INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY.
MLA	Yu, Xiaoqing,et al."Progress on treatment of MET signaling pathway in non-small cell lung cancer".INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2020).