Selective Inhibition of BFL1: It's All about Finding the Right Partner

doi:10.1016/j.chembiol.2020.05.014

	Selective Inhibition of BFL1: It's All about Finding the Right Partner
	Dai, Haiming 3,4; Meng, X. Wei 1,2; Kaufmann, Scott H.1,2
刊名	CELL CHEMICAL BIOLOGY
	2020-06-18
卷号	27
ISSN号	2451-9448
DOI	10.1016/j.chembiol.2020.05.014
通讯作者	Kaufmann, Scott H.(kaufmann.scott@mayo.edu)
英文摘要	In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a BFL1 conformational change that facilitates 4E14 interaction. These results provide insight that will accelerate development of BFL1 inhibitors.
资助项目	NCI[R01 CA166741] ; NCI[R01 CA172503]
WOS关键词	RESISTANCE ; BCL2A1
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000542791900003
资助机构	NCI
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/71290]
专题	中国科学院合肥物质科学研究院
通讯作者	Kaufmann, Scott H.
作者单位	1.Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN 55905 USA 2.Mayo Clin, Div Oncol Res, Rochester, MN 55905 USA 3.Chinese Acad Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China 4.Chinese Acad Sci, Hefei Inst Phys Sci, Inst Hlth & Med Technol, Anhui Prov Key Lab Med Phys & Technol, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Dai, Haiming,Meng, X. Wei,Kaufmann, Scott H.. Selective Inhibition of BFL1: It's All about Finding the Right Partner[J]. CELL CHEMICAL BIOLOGY,2020,27.
APA	Dai, Haiming,Meng, X. Wei,&Kaufmann, Scott H..(2020).Selective Inhibition of BFL1: It's All about Finding the Right Partner.CELL CHEMICAL BIOLOGY,27.
MLA	Dai, Haiming,et al."Selective Inhibition of BFL1: It's All about Finding the Right Partner".CELL CHEMICAL BIOLOGY 27(2020).