Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T

doi:10.3389/fnagi.2020.00259

	Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T
	Wen, Qingqing 5; Yang, Hongyi 4,5; Li, Jiali 3; Zhang, Jin 5; Tong, Haiyang 5; Ye, Qiong 5; Zhong, Kai 1,2,4,5
刊名	FRONTIERS IN AGING NEUROSCIENCE
	2020-08-14
卷号	12
关键词	quantitative susceptibility mapping iron concentration brain aging rhesus monkey high resolution 9 4 T
ISSN号	1663-4365
DOI	10.3389/fnagi.2020.00259
通讯作者	Ye, Qiong(qiong.ye@hmfl.ac.cn)
英文摘要	Iron concentration in the brain has been suggested as a biomarker of pathologic neurodegeneration. However, the iron concentration changes in healthy aging as well. This study aimed to quantify the age-related changes in iron concentration in the gray matter of healthy rhesus monkeys using quantitative susceptibility mapping (QSM). Three-dimensional gradient-echo images of 16 female rhesus monkey brains aged between 2 and 26 years were acquiredin vitro. The susceptibilities in the brain regions of the caudate nucleus (Cd), putamen (Pt), globus pallidus (Gp), and substantia nigra (Sn) were analyzed. The susceptibility varied across different brain regions, with higher levels in the Gp and Sn. Susceptibilities in all analyzed brain regions were linearly correlated with age, yet the plateau period as observed in human brains was absent. This is the firstin vitroreport of the age-related variability of susceptibility in the deep gray matter of rhesus monkey brains at 9.4 T, with an isotropic resolution of 150 mu m. Awareness of age-related changes in susceptibility is vital for the establishment of a baseline to facilitate the differentiation of pathologic neurodegeneration from healthy aging in non-human primate studies.
资助项目	National Natural Science Foundation of China[91649101] ; National Key Research and Development Program of China[2018YFE0205700] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB32030200] ; Hefei Science Center[2017HSCKPRD003] ; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences ; Yunnan Province
WOS关键词	ENABLED DIPOLE INVERSION ; IRON CONCENTRATION ; MAGNETIC-FIELD ; PRIMATE MODELS ; MAPPING QSM ; PHASE DATA ; MRI ; RECONSTRUCTION ; VALIDATION ; COSMOS
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000566190400001
资助机构	National Natural Science Foundation of China ; National Key Research and Development Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Hefei Science Center ; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences ; Yunnan Province
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/70331]
专题	中国科学院合肥物质科学研究院
通讯作者	Ye, Qiong
作者单位	1.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Shanghai, Peoples R China 2.Key Lab Anhui Prov High Field Magnet Resonance Im, Hefei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Zool, Kunming, Yunnan, Peoples R China 4.Univ Sci & Technol China, Hefei, Peoples R China 5.Chinese Acad Sci, Hefei Inst Phys Sci, High Field Magnet Lab, Hefei, Peoples R China
推荐引用方式 GB/T 7714	Wen, Qingqing,Yang, Hongyi,Li, Jiali,et al. Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T[J]. FRONTIERS IN AGING NEUROSCIENCE,2020,12.
APA	Wen, Qingqing.,Yang, Hongyi.,Li, Jiali.,Zhang, Jin.,Tong, Haiyang.,...&Zhong, Kai.(2020).Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T.FRONTIERS IN AGING NEUROSCIENCE,12.
MLA	Wen, Qingqing,et al."Ultra-High-Resolutionin vitroMRI Study of Age-Related Brain Subcortical Susceptibility Alteration in Rhesus Monkeys at 9.4 T".FRONTIERS IN AGING NEUROSCIENCE 12(2020).