XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer

	XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer
刊名	ACTA BIOCHIMICA ET BIOPHYSICA SINICA
	2009
卷号	41
关键词	NUCLEOTIDE-EXCISION-REPAIR PIGMENTOSUM GROUP-F XERODERMA-PIGMENTOSUM DNA-REPAIR GROUP-A TRANSCRIPTION RISK BINDING ERCC1 RNA single nucleotide polymorphism gene-chip XPA XPG nucleotide excision repair non-small cell lung cancer chemotherapy
ISSN号	1672-9145
其他题名	XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer
英文摘要	DNA repair capacity (DRC) is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. We hypothesize that genetic polymorphisms in DNA repair gene XPA (xeroderma pigmentosum group A) and XPG (xeroderma pigmentosum group G) (ERCC5, excision repair cross-complementation group 5), which result in inter-individual differences in DNA repair efficiency, may predict clinical response to platinum agents in advanced non-small cell lung cancer (NSCLC) patients. In this study, we find that the A -> G change of XPA A23G polymorphism significantly increased response to platinum-based chemotherapy. Polymorphism in XPG His46His was associated with a decreased treatment response, but was not statistically significant.
资助项目	[Jiangsu Province Nature Fund] ; [Medicine Science Technology Research 'Eleventh Five-Year' Program of PLA] ; [Focal Project of Nanjing Medicine Technology Development]
语种	英语
CSCD记录号	CSCD:3613398
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/59146]
专题	中国科学院合肥物质科学研究院
推荐引用方式 GB/T 7714	. XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2009,41.
APA	(2009).XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,41.
MLA	"XPA A23G polymorphism is associated with the elevated response to platinum-based chemotherapy in advanced non-small cell lung cancer".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 41(2009).