Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity

doi:10.5012/bkcs.2010.31.11.3359

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	Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity
	Yang, Jin-Wei 1,5; Li, Cui 2; He, Xiao-Peng 2,3; Zhao, Hong 1,5; Gao, Li-Xin 4; Zhang, Wei 4; Shi, Xiao-Xin 2; Tang, Yun 2; Li, Jia4 ; Chen, Guo-Rong 1,5
刊名	BULLETIN OF THE KOREAN CHEMICAL SOCIETY
	2010-11-20
卷号	31 期号:11 页码:3359-3365
关键词	Click chemistry Microwave irradiation Carbohydrate-based drug discovery PTP1B inhibitor Docking simulation
ISSN号	0253-2964
DOI	10.5012/bkcs.2010.31.11.3359
文献子类	Article
英文摘要	The incorporation of microwave irradiation with the prevalent "click chemistry" is currently of considerable synthetic interest We describe here the introduction of such laboratorial shortcut into carbohydrate-based drug discovery, resulting in the rapid formation of a series of triazole-linked salicylic beta-D-O-glycosides with biological activities All "clicked" products were achieved in excellent yields (approximate to 90%) within only a quarter In addition, based on the structural characteristics of the afforded glycomimetics, their inhibitory activities were evaluated toward protein tyrosine phosphatases 1B (PTP1B) and a panel of homologous protein tyrosine phosphatases (PTPs) Docking simulation A as also conducted to plausibly propose binding modes of this glycosyl salicylate series with the enzymatic target
资助项目	National Natural Science Foundation of China[20876045] ; National Science & Technology Major Project of China[2009 ZX09302-001] ; Shanghai Science and Technology Community[10410702700] ; Shanghai Science and Technology Community[08DZ2291300] ; Chinese Academy of Sciences[KSCX2-YW-R-168] ; French Embassy in China[00000000]
WOS关键词	TYROSINE-PHOSPHATASE 1B ; MEDICAL APPLICATIONS ; ACID ; DISCOVERY ; SCAFFOLDS ; DRUGS
WOS研究方向	Chemistry
语种	英语
出版者	KOREAN CHEMICAL SOC
WOS记录号	WOS:000284794100055
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278716]
专题	国家新药筛选中心药物安全性评价中心
通讯作者	Li, Jia
作者单位	1.E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 3.CNRS, ENS Cachan, PPSM, F-94230 Cachan, France 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China; 5.E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;
推荐引用方式 GB/T 7714	Yang, Jin-Wei,Li, Cui,He, Xiao-Peng,et al. Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity[J]. BULLETIN OF THE KOREAN CHEMICAL SOCIETY,2010,31(11):3359-3365.
APA	Yang, Jin-Wei.,Li, Cui.,He, Xiao-Peng.,Zhao, Hong.,Gao, Li-Xin.,...&Chen, Guo-Rong.(2010).Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity.BULLETIN OF THE KOREAN CHEMICAL SOCIETY,31(11),3359-3365.
MLA	Yang, Jin-Wei,et al."Microwave-Accelerated Click Chemistry: Expeditious Synthesis of Novel Triazole-linked Salicylic beta-D-O-Glycosides with PTP1B Inhibitory Activity".BULLETIN OF THE KOREAN CHEMICAL SOCIETY 31.11(2010):3359-3365.