L-Stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement

doi:10.1016/j.neulet.2013.10.066

	L-Stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement
	Ma, Baomiao 3; Yue, Kai 3; Chen, Lin 3; Tian, Xiang 3; Ru, Qin 3; Gan, Yongping 1; Wang, Daisong 1; Jin, Guozhang2,3 ; Li, Chaoying 3
刊名	NEUROSCIENCE LETTERS
	2014-01-24
卷号	559 页码:67-71
关键词	L-Stepholidine Heroin Dopamine receptor Self-administration Relapse
ISSN号	0304-3940
DOI	10.1016/j.neulet.2013.10.066
文献子类	Article
英文摘要	L-Stepholidine (L-SPD), an alkaloid extract of the Chinese herb Stephania intermedia, is the first compound known to exhibit mixed dopamine D1 receptor agonist/D2 antagonist properties and is a potential medication for the treatment of opiate addiction. The aim of the present study was to investigate the effects of pretreatment with L-SPD on heroin-seeking behavior induced by heroin priming. Male Sprague-Dawley rats were trained to self-administer heroin (0.05 mg/kg per infusion) under a fixed ratio 1 schedule for 12 consecutive days and nose-poke responding was extinguished for 12 days, after which reinstatement of drug seeking was induced by heroin priming. Pretreatment with L-SPD (2.5, 5.0 and 10.0 mg/kg, i.p.) inhibited the heroin-induced reinstatement of heroin-seeking behavior. Importantly, L-SPD did not affect locomotion, indicating that the observed effects of L-SPD on reinstatement are not the result of motor impairments. The present data suggested that L-SPD inhibits heroin-induced reinstatement and its potential for the treatment of heroin relapse. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
资助项目	Wuhan Science and Technology Foundation[201150699189-23] ; Hubei Education Foundation[Q20123405] ; Natural Science Foundation of Hubei[2012FFB03402] ; National Natural Science Foundation of China[81302762]
WOS关键词	CONDITIONED PLACE PREFERENCE ; COCAINE-SEEKING BEHAVIOR ; NUCLEUS-ACCUMBENS ; SQUIRREL-MONKEYS ; RATS ; RELAPSE ; DRUG ; ADDICTION ; D-1 ; WITHDRAWAL
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	ELSEVIER IRELAND LTD
WOS记录号	WOS:000331021900013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/277223]
专题	院士及顾问专家
通讯作者	Li, Chaoying
作者单位	1.Hubei Publ Secur Bur, Drug Prevent & Educ Ctr, Wuhan 430070, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201213, Peoples R China 3.Jianghan Univ, Wuhan Inst Biomed Sci, Wuhan 430056, Peoples R China;
推荐引用方式 GB/T 7714	Ma, Baomiao,Yue, Kai,Chen, Lin,et al. L-Stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement[J]. NEUROSCIENCE LETTERS,2014,559:67-71.
APA	Ma, Baomiao.,Yue, Kai.,Chen, Lin.,Tian, Xiang.,Ru, Qin.,...&Li, Chaoying.(2014).L-Stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement.NEUROSCIENCE LETTERS,559,67-71.
MLA	Ma, Baomiao,et al."L-Stepholidine, a natural dopamine receptor D1 agonist and D2 antagonist, inhibits heroin-induced reinstatement".NEUROSCIENCE LETTERS 559(2014):67-71.