Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity

doi:10.1016/j.jff.2015.06.057

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	Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity
	Zhu, Yan 2,4; Xu, Junjiu 3; Li, Zhao 2,4; Xie, Shuwu 2,4; Thou, Jieyun 2,4; Guo, Xiangjie 2,4; Zhou, Xianying 2,4; Li, Guoting 2; Zhong, Ruihua 2; Ma, Aying 1,2
刊名	JOURNAL OF FUNCTIONAL FOODS
	2015-10
卷号	18 页码:73-82
关键词	Ginsenoside Rh2 ER alpha c-Src p38 MAPK Uterine leiomyoma
ISSN号	1756-4646
DOI	10.1016/j.jff.2015.06.057
文献子类	Article
英文摘要	Panax ginseng is widely used as a functional food in Asia because of its bioactivities. Here, we report that ginsenoside Rh2, an extract of red Panax ginseng, suppressed growth of uterine leiomyomas (ULs) in a rat model and decreased serum hormone levels in a dose-dependent manner. Rh2 also inhibited the growth of cultured human UL cells in vitro. After Rh2 treatment, cells showed morphological changes that were consistent with apoptosis. Using ELISA, real-time RT-PCR, and Western blot methods, we found that Rh2 significantly reduced the activity of oestrogen receptor alpha (ER alpha) and c-Src, increased p38 MAPK activity, and reversed ER alpha activity mediated by PP2 and SB203580, specific inhibitors of c-Src and p38 MAPK, respectively, in UL cells. These findings provide a novel mechanism for the anti-proliferative efficacy of Rh2 that likely involves regulating ER alpha/Src/p38 MAPK activity. (C) 2015 Elsevier Ltd. All rights reserved.
WOS关键词	ESTROGEN-RECEPTOR-ALPHA ; BREAST-CANCER ; ER-ALPHA ; C-SRC ; MODEL ; PHOSPHORYLATION ; EXPRESSION ; CELLS ; GESTRINONE ; ACTIVATION
WOS研究方向	Food Science & Technology
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000367757400008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276375]
专题	药物安全性评价中心
通讯作者	Zhu, Yan
作者单位	1.Fudan Univ, Shanghai 200032, Peoples R China 2.Shanghai Inst Planned Parenthood Res, Dept Reprod Pharmacol, Shanghai 200032, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, Shanghai 201203, Peoples R China; 4.Shanghai ETR Ctr Reprod Hlth Drug & Devices, NPFPC Key Lab Contracept & Devices, Shanghai 200032, Peoples R China;
推荐引用方式 GB/T 7714	Zhu, Yan,Xu, Junjiu,Li, Zhao,et al. Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity[J]. JOURNAL OF FUNCTIONAL FOODS,2015,18:73-82.
APA	Zhu, Yan.,Xu, Junjiu.,Li, Zhao.,Xie, Shuwu.,Thou, Jieyun.,...&Ma, Aying.(2015).Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity.JOURNAL OF FUNCTIONAL FOODS,18,73-82.
MLA	Zhu, Yan,et al."Ginsenoside Rh2 suppresses growth of uterine leiomyoma in vitro and in vivo and may regulate ER alpha/c-Src/p38 MAPK activity".JOURNAL OF FUNCTIONAL FOODS 18(2015):73-82.