Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity

doi:10.1007/s13318-015-0306-1

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	Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity
	Ma, Leilei 1; He, Lei 3; Wang, Le 1; Li, Li 2; Lin, Xuena 4; Pan, Guoyu1
刊名	EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
	2016-06
卷号	41 期号:3 页码:199-210
ISSN号	0378-7966
DOI	10.1007/s13318-015-0306-1
文献子类	Review
英文摘要	Diabetes mellitus is becoming an increasingly prevalent disease that concerns patients and healthcare professionals worldwide. Among many anti-diabetic agents in clinical uses, numerous reports are available on their altered pharmacokinetics because of changes in the expression of drug transporters and metabolic enzymes under diabetic states. These changes may affect the safety and efficacy of therapeutic agents and/or drug-drug interaction with co-administered agents. Therefore, the changes in transporter expression should be identified, and the underlying mechanisms should be clarified. This review summarizes the progress of recent studies on the alterations in important uptake and efflux transporters in liver of diabetic animals and their regulatory pathways.
资助项目	National Science Foundation of China[81302836] ; National Science Foundation of China[81573499] ; Key Projects of National Science and Technology Program, China[2012ZX09301001-006] ; Key Projects of National Science and Technology Program, China[2012ZX09302003] ; Key Projects of National Science and Technology Program, China[2012ZX09301001]
WOS关键词	PREGNANE-X-RECEPTOR ; ORGANIC ANION TRANSPORTER ; CANCER RESISTANCE PROTEIN ; HEPATOCYTE NUCLEAR FACTOR-1-ALPHA ; CONSTITUTIVE ANDROSTANE RECEPTOR ; BLOOD-BRAIN-BARRIER ; MULTIDRUG-RESISTANCE ; P-GLYCOPROTEIN ; ACTIVATED RECEPTOR ; DOWN-REGULATION
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	SPRINGER FRANCE
WOS记录号	WOS:000376250700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/276029]
专题	药物安全性评价中心
通讯作者	Pan, Guoyu
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.US FDA, Ctr Drug Evaluat & Res, Off Clin Pharmacol, 10903 New Hampshire Ave,Bldg 51,Room 3172, Silver Spring, MD 20993 USA; 3.InCROM CHINA, Quyang Rd 972, Shanghai 200437, Peoples R China; 4.Novartis Inst Biomed Res, Metab & Pharmacokinet, Cambridge, MA 02139 USA
推荐引用方式 GB/T 7714	Ma, Leilei,He, Lei,Wang, Le,et al. Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity[J]. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,2016,41(3):199-210.
APA	Ma, Leilei,He, Lei,Wang, Le,Li, Li,Lin, Xuena,&Pan, Guoyu.(2016).Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity.EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS,41(3),199-210.
MLA	Ma, Leilei,et al."Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity".EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 41.3(2016):199-210.