beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123

doi:10.1016/j.tet.2016.08.048

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	beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123
	Saetang, Praphatsorn 1,2; Rukachaisirikul, Vatcharin 1,2; Phongpaichit, Souwalak 5,6; Sakayaroj, Jariya 4; Shi, Xiaofan 3; Chen, Jing3 ; Shen, Xu3
刊名	TETRAHEDRON
	2016-10-13
卷号	72 期号:41 页码:6421-6427
关键词	beta-Resorcylic macrolide Octahydronaphthalene derivative Antifungal activity Cytotoxic activity Protection of pancreatic beta-cells
ISSN号	0040-4020
DOI	10.1016/j.tet.2016.08.048
文献子类	Article
英文摘要	Five new metabolites including four beta-resorcylic macrolides 1-4 and one octahydronaphthalene derivative 5 were isolated from a seagrass-derived fungus Fusarium sp. PSU-ES123 together with seven known compounds. Their structures were characterized by analysis of the spectroscopic data. The absolute configuration was determined by Mosher's method and circular dichroism spectroscopy. Compound I displayed weak antifungal activity against Cryptococcus neoformans with an MIC value of 128 mu g/mL and no cytotoxic activity against noncancerous Vero cell lines. In addition, known zearalenone displayed a protective activity against INS -1 832/13 pancreatic beta-cells by an EC50 value of 6.09 mu M and was noncytotoxic to Vero cells. (C) 2016 Elsevier Ltd. All rights reserved.
资助项目	NSTDA Chair Professor grant of the Crown Property Bureau Foundation[00000000] ; National Science and Technology Development Agency[00000000] ; Thailand Research Fund[DBG5980001] ; NSFC-TRF[81561148011] ; Faculty of Science, Prince of Songkla University[00000000] ; Center of Excellence for Innovation in Chemistry (PERCH-CIC)[00000000] ; Graduate School, Prince of Songkla University[00000000] ; Department of Chemistry, Faculty of Science, Prince of Songkla University[00000000]
WOS关键词	ZEARALENONE PRODUCTION ; TOXIN EQUISETIN ; A-C ; METABOLITES ; ANTIBACTERIAL
WOS研究方向	Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000384776300018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/275857]
专题	药物安全性评价中心
通讯作者	Rukachaisirikul, Vatcharin
作者单位	1.Prince Songkla Univ, Fac Sci, Ctr Excellence Innovat Chem, Hat Yai 90112, Songkhla, Thailand; 2.Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand; 3.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 4.Natl Ctr Genet Engn & Biotechnol BIOTEC, Thailand Sci Pk, Klongluang 12120, Pathumthani, Thailand; 5.Prince Songkla Univ, Fac Sci, Nat Prod Res Ctr Excellence, Hat Yai 90112, Songkhla, Thailand; 6.Prince Songkla Univ, Fac Sci, Dept Microbiol, Hat Yai 90112, Songkhla, Thailand;
推荐引用方式 GB/T 7714	Saetang, Praphatsorn,Rukachaisirikul, Vatcharin,Phongpaichit, Souwalak,et al. beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123[J]. TETRAHEDRON,2016,72(41):6421-6427.
APA	Saetang, Praphatsorn.,Rukachaisirikul, Vatcharin.,Phongpaichit, Souwalak.,Sakayaroj, Jariya.,Shi, Xiaofan.,...&Shen, Xu.(2016).beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123.TETRAHEDRON,72(41),6421-6427.
MLA	Saetang, Praphatsorn,et al."beta-Resorcylic macrolide and octahydronaphthalene derivatives from a seagrass-derived fungus Fusarium sp PSU-ES123".TETRAHEDRON 72.41(2016):6421-6427.