Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression

doi:10.1097/WNR.0b013e3282f942a8

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	Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression
	Li, Ting 1,2; Han, Dong 2; Chen, Juan 2; Yu, Xiuju 2; Zhang, Guang-Yi 1,2
刊名	NEUROREPORT
	2008-04-16
卷号	19 期号:6 页码:647-651
关键词	antisense oligodeoxynucleotides cerebral ischemia c-Jun NH2-terminal kinase hematopietic progenitor kinase 1
ISSN号	0959-4965
DOI	10.1097/WNR.0b013e3282f942a8
文献子类	Article
英文摘要	In this study, we investigated the role of hematopietic progenitor kinase 1 (HPK1) in delayed neuronal damage after cerebral ischemia and the possible regulatory mechanisms of this event. Our data show that tyrosine phosphorylation of HPK1 was significantly increased at 6 h of ischemic-reperfusion compared with sham control. The increase in p-HPK1, p-MLK3, p-MKK7, and p-JNK3 was attenuated by HPK1 antisense oligodeoxynucleotides intra-cerebroventricular infusion, but not MS-ODNs or vehicle. Intra-cerebroventricular infusion of antisense oligodeoxynucleotides also increased the number of surviving pyramidal neurons, whereas MS-ODNs or vehicle (TE) groups had no effects. These results indicate that knockdown of HPK1 expression provides neuroprotection through downregulation activation of the MLK3-MKK7-JNK3 pathway following cerebral ischemia in the rat hippocampus CA1 subfield.
WOS关键词	HEMATOPOIETIC PROGENITOR KINASE-1 ; N-TERMINAL KINASE ; RAT HIPPOCAMPUS ; CEREBRAL-ISCHEMIA ; PROTEIN-KINASE ; MIXED LINEAGE ; ACTIVATION ; HPK1 ; JNK3 ; APOPTOSIS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	LIPPINCOTT WILLIAMS & WILKINS
WOS记录号	WOS:000255301300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/272938]
专题	国家新药筛选中心
通讯作者	Zhang, Guang-Yi
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China 2.Xuzhou Med Coll, Res Ctr Biochem & Mol Biol, Jiangsu Key Lab Brain Dis Bioinormat, Jiangsu 221002, Peoples R China;
推荐引用方式 GB/T 7714	Li, Ting,Han, Dong,Chen, Juan,et al. Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression[J]. NEUROREPORT,2008,19(6):647-651.
APA	Li, Ting,Han, Dong,Chen, Juan,Yu, Xiuju,&Zhang, Guang-Yi.(2008).Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression.NEUROREPORT,19(6),647-651.
MLA	Li, Ting,et al."Neuroprotection against ischemic brain injury by knockdown of hematopietic progenitor kinase 1 expression".NEUROREPORT 19.6(2008):647-651.