Synthetic process of telavancin

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	Synthetic process of telavancin
	Xiong Lun 2; Guan Dongliang 1; Li Jian 2; Huang Wei 1
刊名	Journal of China Pharmaceutical University
	2017
卷号	48 期号:2 页码:172-177
关键词	vancomycin telavancin synthetic process
ISSN号	1000-5048
其他题名	特拉万星合成工艺研究
文献子类	Article
英文摘要	New process reported the synthesis of telavancin using decyl alcohol as the starting material.After methanesulfonylation,nucleophilic substitution with ethanolamine,Fmoc protection,and Parikh-Doering oxidation,the intermdiate N-(9-fluorenyl-9-methoxycarbonyl) decylaminoethyl acetaldehyde (5) was obtained.Vancomycin hydrochloride and intermediate 5 were then subject to reductive amination reaction,Fmoc deprotection,and Mannich reaction to give the telavancin product.The process have been deeply studied on the two key reactions of reductive amination and Mannich reaction,and the reaction conditions have been optimized.The overall yield is 46% based on starting material vancomycin.
资助项目	国家自然科学基金资助项目[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5964872
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269208]
专题	药物安全性评价中心
作者单位	1.Shanghai Institute of Materia Media,Chinese Academy of Sciences, Shanghai 201203, China. 2.College of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.;
推荐引用方式 GB/T 7714	Xiong Lun,Guan Dongliang,Li Jian,et al. Synthetic process of telavancin[J]. Journal of China Pharmaceutical University,2017,48(2):172-177.
APA	Xiong Lun,Guan Dongliang,Li Jian,&Huang Wei.(2017).Synthetic process of telavancin.Journal of China Pharmaceutical University,48(2),172-177.
MLA	Xiong Lun,et al."Synthetic process of telavancin".Journal of China Pharmaceutical University 48.2(2017):172-177.