Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists

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	Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists
	Liu Qing; He Min; Zhou Caihong; Wang Mingwei
刊名	Chinese Bulletin of Life Sciences
	2012
卷号	24 期号:7 页码:626-633
关键词	glucagon-like peptide-1(GLP-1) cyclobutane derivatives diabetes
ISSN号	1004-0374
其他题名	取代环丁烷结构的非肽类胰高血糖素样肽-1受体激动剂
文献子类	Article
英文摘要	Application of glucagon-like peptide-1(GLP-1) to treat type 2 diabetes has become a focal point in the study of metabolic diseases in recent years.Of particular interest is the unique mechanisms of action relative to GLP-1.It exerts multiple effects on the pathogenesis of type 2 diabetes.While effectively lowering blood glucose levels,it does not cause hypoglycemia but reduces body weight.However,GLP-1 and its peptidic mimetics require frequent injections that limits their wide use.This paper briefly reviews the discovery and pharmacological characterization of a class of novel cyclobutane derivatives as non-peptidic GLP-1 receptor agonists including in vivo efficacies on diabetes and obesity.
资助项目	国家重大科技专项十一五和十二五计划[00000000] ; 中国科学院重大项目[00000000] ; 方向性项目[00000000] ; 上海市科委项目[00000000] ; 诺和诺德-中国科学院研究基金[00000000]
WOS研究方向	Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4618183
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267823]
专题	国家新药筛选中心
通讯作者	Wang Mingwei
作者单位	The National Center for Drug Screening,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	Liu Qing,He Min,Zhou Caihong,et al. Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists[J]. Chinese Bulletin of Life Sciences,2012,24(7):626-633.
APA	Liu Qing,He Min,Zhou Caihong,&Wang Mingwei.(2012).Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists.Chinese Bulletin of Life Sciences,24(7),626-633.
MLA	Liu Qing,et al."Substituted cyclobutane derivatives as non-peptidic GLP-1 receptor agonists".Chinese Bulletin of Life Sciences 24.7(2012):626-633.