Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells

doi:10.1039/c8nj02027b

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	Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells
	Zhang, Jianqing 1,2; Jin, Qinghao 1; Li, Shiyou 3; Wu, Jia 1; Wang, Zhen3 ; Hou, Jinjun1 ; Qu, Hua 1; Long, Huali 1; Wu, Wanying1 ; Guo, Dean1,2
刊名	NEW JOURNAL OF CHEMISTRY
	2018-08-21
卷号	42 期号:16 页码:13414-13420
ISSN号	1144-0546
DOI	10.1039/c8nj02027b
文献子类	Article
英文摘要	Two new sesquiterpenes (1-2) and three new nor-sesquiterpenes (3-5) were obtained from the rhizome of Alisma orientale (Sam.) Juzep, one of which (2) possessed an unprecedented cyclopentene and furanone containing natural skeleton. Their structures and relative stereochemistry were elucidated by NMR spectroscopy (H-1 and C-13 NMR, HSQC, HMBC, NOESY) and electronic circular dichroism (ECD) and HR-ESI-MS data analyses. Two plausible biosynthetic pathways for compound 1 and 2 were discussed. The nephrotoxicities of these compounds were evaluated on normal human HK2 cells by high content screening, and neither the MeOH extract nor the compounds possessed potential nephrotoxicity in vitro.
资助项目	Shanghai Municipal Science and Technology Commission[15DZ05022800] ; National Standardization Program for Chinese Medicine[ZYBZH-K-LN-01]
WOS关键词	CONTENT SCREENING TECHNOLOGY ; DRUG-INDUCED HEPATOTOXICITY ; TRITERPENES ; 23-ACETATE ; AUTOPHAGY ; RATS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000445827700019
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279613]
专题	上海中药现代化研究中心
通讯作者	Wu, Wanying; Guo, Dean
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China; 3.Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jianqing,Jin, Qinghao,Li, Shiyou,et al. Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells[J]. NEW JOURNAL OF CHEMISTRY,2018,42(16):13414-13420.
APA	Zhang, Jianqing.,Jin, Qinghao.,Li, Shiyou.,Wu, Jia.,Wang, Zhen.,...&Guo, Dean.(2018).Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells.NEW JOURNAL OF CHEMISTRY,42(16),13414-13420.
MLA	Zhang, Jianqing,et al."Orientalol L-P, novel sesquiterpenes from the rhizome of Alisma orientale (Sam.) Juzep and their nephrotoxicity on HK2 cells".NEW JOURNAL OF CHEMISTRY 42.16(2018):13414-13420.