Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica

doi:10.1016/j.phytochem.2018.07.008

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 上海中药现代化研究中心

	Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica
	Jin, Qinghao 2,3; Lee, Jin Woo 2; Jang, Hari 2; Lee, Hye Lim 2; Kim, Jun Gu 2; Wu, Wanying3 ; Lee, Dongho 4; Kim, Eun-Hee 1; Kim, Youngsoo 2; Hong, Jin Tae 2
刊名	PHYTOCHEMISTRY
	2018-11
卷号	155 页码:107-113
关键词	Inula japonica Asteraceae Sesquiterpene trimer Sesquiterpenes dimer Cytotoxic activity Nitric oxide
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2018.07.008
文献子类	Article
英文摘要	An undescribed unusual sesquiterpene trimer and three sesquiterpene dimers were isolated from the flowers of Inula japonica. Their structures were elucidated by extensive analysis of 1D and 2D NMR spectroscopic data as well as HRESIMS data. Inulajaponicolide A has an undescribed carbon skeleton comprising of one xanthanolide and two guaianolide units with the linkage mode of C-11/C-3' and C-11'C-1" via a Diels-Alder cycloaddition reaction. Inulajaponicolides C and D exhibited moderate cytotoxic activity against A 549 and NCI-H460 human cancer cell lines with IC50 values ranging from 8.5 to 17.8 mu M. Inulajaponicolides A-D and lineariifolianoid A possessed significant inhibitory potency against nitric oxide production in LPS-induced RAW264.7 cells with IC50 values ranging from 1.0 to 4.1 M.
资助项目	Medical Research Center Program (MRC) through the National Research Foundation of Korea[2017R1A5A2015541]
WOS关键词	A-D ; CARPESIUM-FABERI ; LACTONE DIMERS ; CYTOTOXICITY ; THUNB ; CELLS
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000447483900013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279523]
专题	上海中药现代化研究中心
通讯作者	Hwan, Bang Yeon
作者单位	1.Korea Basic Sci Inst, Prot Struct Grp, Ochang 28119, Chungbuk, South Korea 2.Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, South Korea; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.Korea Univ, Dept Biosyst & Biotechnol, Coll Life Sci & Biotechnol, Seoul 02841, South Korea;
推荐引用方式 GB/T 7714	Jin, Qinghao,Lee, Jin Woo,Jang, Hari,et al. Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica[J]. PHYTOCHEMISTRY,2018,155:107-113.
APA	Jin, Qinghao.,Lee, Jin Woo.,Jang, Hari.,Lee, Hye Lim.,Kim, Jun Gu.,...&Hwan, Bang Yeon.(2018).Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica.PHYTOCHEMISTRY,155,107-113.
MLA	Jin, Qinghao,et al."Dimeric- and trimeric sesquiterpenes from the flower of Inula japonica".PHYTOCHEMISTRY 155(2018):107-113.