Possible target-related proteins of salvianolic acids in rat platelets

doi:10.1016/j.phytol.2008.07.003

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	Possible target-related proteins of salvianolic acids in rat platelets
	Yao, Yan 1,2; Liu, Ai-Hua 1; Wu, Wan-Ying1 ; Guan, Shu-Hong1 ; Jiang, Bao-Hong1 ; Yang, Min 1; Bi, Kai-Shun 2; Liu, Xuan 1; Guo, De-An1
刊名	PHYTOCHEMISTRY LETTERS
	2008-11-03
卷号	1 期号:3 页码:135-138
关键词	Salvianolic acids Platelet 2-DE Proteomics
ISSN号	1874-3900
DOI	10.1016/j.phytol.2008.07.003
文献子类	Article
英文摘要	Salvianolic acids (SAs) extracted from Salvia miltiorrhiza could inhibit ADP-induced aggregation of rat washed platelets. To elucidate the cellular mechanism of the inhibitive effect on platelet aggregation, a proteomic method was used to find the possible target-related proteins of SA in platelets. Treatment of 150 mu g/ml SA caused the regulation of platelet levels of 12 proteins, which play important roles in calcium homeostasis, antioxidant system and cytoskeleton structure. The proteomic result was also confirmed by Western blotting. (C) 2008 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
资助项目	Chinese Academy of Sciences[SIMM709QN-14] ; Ministry of Science and Technology of the People's Republic of China[2006DFB31860] ; Science and Technology Commission of Shanghai Municipality[064319052]
WOS关键词	AGGREGATION
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000263033900002
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279437]
专题	上海中药现代化研究中心
通讯作者	Liu, Xuan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Yao, Yan,Liu, Ai-Hua,Wu, Wan-Ying,et al. Possible target-related proteins of salvianolic acids in rat platelets[J]. PHYTOCHEMISTRY LETTERS,2008,1(3):135-138.
APA	Yao, Yan.,Liu, Ai-Hua.,Wu, Wan-Ying.,Guan, Shu-Hong.,Jiang, Bao-Hong.,...&Guo, De-An.(2008).Possible target-related proteins of salvianolic acids in rat platelets.PHYTOCHEMISTRY LETTERS,1(3),135-138.
MLA	Yao, Yan,et al."Possible target-related proteins of salvianolic acids in rat platelets".PHYTOCHEMISTRY LETTERS 1.3(2008):135-138.