Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo

doi:10.1016/j.fct.2009.03.038

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	Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo
	Jiang, Baohong2 ; Zhang, Lin 2; Wang, Yingchun 2; Li, Ming2 ; Wu, Wanying2 ; Guan, Shuhong2 ; Liu, Xuan 2; Yang, Min 2; Wang, Junchen 1; Guo, De-an2
刊名	FOOD AND CHEMICAL TOXICOLOGY
	2009-07
卷号	47 期号:7 页码:1538-1544
关键词	Doxorubicin Tanshinone IIA sodium sulfonate Cardiomyopathy
ISSN号	0278-6915
DOI	10.1016/j.fct.2009.03.038
文献子类	Article
英文摘要	Although doxorubicin (DXR) is an effective antineoplastic agent; the serious cardiotoxicity mediated by the production of reactive oxygen species has remained a considerable clinical problem. Our hypothesis is that tanshinone HA sodium sulfonate (TSNIIA-SS), which holds significant affects on cardioprotection in clinic, protects against DXR-induced cardiotoxicity. In vitro investigation on H9c2 cell line, as well as in vivo study in animal model of DXR-induced chronic cardiomyopathy were performed. TSNIIA-SS significantly increased cell viability and ameliorated apoptosis of DXR-injured H9c2 cells using CCK-8 assay and Hoechst 33342 stain respectively. Furthermore. the cardio-protective effects of TSNIIA-SS were confirmed with decreasing ST-interval and QRS interval by electrocardiography (ECG); improving appearance of myocardium with haematoxylin and eosin (H&E) stain; increasing myocardial tensile strength using tension to rupture (TTR) assay and decreasing fibrosis through picric-sirius red staining comparing with those receiving DXR alone. These data have provided the considerable evidences that TSNIIA-SS is a protective agent against DXR-induced cardiac injury. (C) 2009 Elsevier Ltd. All rights reserved.
资助项目	International Science and Technology Cooperation Project[2006DFB31860] ; Ministry of Science and Technology of China[2006BA108B03-03]
WOS关键词	RAT CARDIAC-CELLS ; SALVIA-MILTIORRHIZA ; OXIDATIVE STRESS ; MICE ; CARDIOMYOPATHY ; HYPERTROPHY ; SUPPRESSION ; APOPTOSIS ; DAMAGE ; MODEL
WOS研究方向	Food Science & Technology ; Toxicology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000267739300021
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279198]
专题	上海中药现代化研究中心
通讯作者	Jiang, Baohong
作者单位	1.Tongji Univ, Dept Pathol, Dongfang Hosp, Shanghai 200120, Peoples R China 2.Chinese Acad Sci, Shanghai Res Ctr Modernizat Tradit Chinese Med, Shanghai Inst Mat Med, Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China;
推荐引用方式 GB/T 7714	Jiang, Baohong,Zhang, Lin,Wang, Yingchun,et al. Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo[J]. FOOD AND CHEMICAL TOXICOLOGY,2009,47(7):1538-1544.
APA	Jiang, Baohong.,Zhang, Lin.,Wang, Yingchun.,Li, Ming.,Wu, Wanying.,...&Guo, De-an.(2009).Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo.FOOD AND CHEMICAL TOXICOLOGY,47(7),1538-1544.
MLA	Jiang, Baohong,et al."Tanshinone IIA sodium sulfonate protects against cardiotoxicity induced by doxorubicin in vitro and in vivo".FOOD AND CHEMICAL TOXICOLOGY 47.7(2009):1538-1544.