Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction

doi:10.1002/bmc.1743

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	Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction
	Jiang, Weixin 2; Jin, Di 1,2; Li, Zhixiong1 ; Sun, Zhaolin 1; Chen, Mingcang 1; Wu, Bin 1; Huang, Chenggang1
刊名	BIOMEDICAL CHROMATOGRAPHY
	2012-07
卷号	26 期号:7 页码:863-868
关键词	Paederia scandens HPLC-MSn metabolites iridoid glucosides urine serum
ISSN号	0269-3879
DOI	10.1002/bmc.1743
文献子类	Article
英文摘要	Paederia scandens (Lour.) Merri. (Jishiteng in Chinese) is a Chinese traditional medicine widely used in treating various diseases. However, its active components have remained unknown. In the present study, a rapid and sensitive method by high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC-MSn) techniques was employed to investigate the absorbed constituents in rats after oral administration of Paederia scandens decoction. By comparing their MS data with those of authentic compounds and published data, a total of six compounds (paederosid, 1; paederosidic acid, 2; paederosidic acid methyl ester, 3; 6-hydroxy geniposide, 4; asperuloside, 5; and deacetyl asperuloside, 6) were identified in the P. scandens decoction samples. In addition, a total of seven compounds, including three iridoid glucosides and four of their metabolites, were identified in rat urine samples after administration. In addition, six compounds, including four iridoid glucosides and two of their metabolites, were identified in rat serum samples after administration. Our results significantly narrow the range of potentially active compounds in P. scandens decoction, and build a solid foundation for future research on its mechanism. Copyright (c) 2011 John Wiley & Sons, Ltd.
资助项目	National Science and Technology Major Project 'Key New Drug Creationand Manufacturing Program', China[2009ZX09301-001] ; Science and Technology Commission of Shanghai Municipality[08DZ1971402]
WOS关键词	IONIZATION-MASS-SPECTROMETRY ; LC-MS/MS ; MAJOR METABOLITES ; IDENTIFICATION ; URINE ; MS ; SAPONINS ; EXTRACT ; SERUM
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	WILEY-BLACKWELL
WOS记录号	WOS:000304989300013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/278035]
专题	上海中药现代化研究中心
通讯作者	Huang, Chenggang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Harbin Univ Commerce, Harbin 150076, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Weixin,Jin, Di,Li, Zhixiong,et al. Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction[J]. BIOMEDICAL CHROMATOGRAPHY,2012,26(7):863-868.
APA	Jiang, Weixin.,Jin, Di.,Li, Zhixiong.,Sun, Zhaolin.,Chen, Mingcang.,...&Huang, Chenggang.(2012).Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction.BIOMEDICAL CHROMATOGRAPHY,26(7),863-868.
MLA	Jiang, Weixin,et al."Characterization of multiple absorbed constituents in rats after oral administration of Paederia scandens decoction".BIOMEDICAL CHROMATOGRAPHY 26.7(2012):863-868.